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Merck
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重要文件

SML1537

Sigma-Aldrich

Cantharidin Ready Made Solution

0.1 mg/mL in DMSO

同義詞:

2,3-二甲基-7-氧杂-双环[2.2.1]庚烷-2,3-二羧酸酐, Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione, 六氢-3α,7α-二甲基-4,7-环氧异苯并呋喃-1,3-二酮, 班蝥酸酐

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About This Item

經驗公式(希爾表示法):
C10H12O4
CAS號碼:
分子量::
196.20
EC號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77
暫時無法取得訂價和供貨情況

生物源

insect

品質等級

形狀

solution

濃度

0.1 mg/mL in DMSO

運輸包裝

ambient

儲存溫度

2-8°C

SMILES 字串

O1[C@@H]2[C@]3([C@@]([C@H]1CC2)(C(=O)OC3=O)C)C

InChI

1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-

InChI 密鑰

DHZBEENLJMYSHQ-XCVPVQRUSA-N

生化/生理作用

Cantharidin inhibits protein phosphatase 2A.
It is a component of mylabris, a traditional Chinese medicine. Cantharidin exhibits anti-tumor activity.[1] In addition, cantharidin can work against multidrug-resistant cells.[2] In the epidermis, it causes release of neutral serine proteases, leading to degeneration of the desmosmal plaque. This results in acantholysis and intraepidermal blistering as well as skin lysis.[3] PP2A is involved in the cell cycle, cell death, growth and cell-fate determination.[1]

其他說明

Stable for at least two years at 2-8° C.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

188.6 °F

閃點(°C)

87 °C


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Wei Li et al.
Cancer science, 101(5), 1226-1233 (2010-03-25)
Cantharidin is an active constituent of mylabris, a traditional Chinese medicine. It is a potent and selective inhibitor of protein phosphatase 2A (PP2A) that plays an important role in control of cell cycle, apoptosis, and cell-fate determination. Owing to its
L Moed et al.
Archives of dermatology, 137(10), 1357-1360 (2001-10-27)
Cantharidin, a vesicant produced by beetles in the order Coleoptera, has a long history in both folk and traditional medicine. In dermatology, topical cantharidin has long been used to treat warts and molluscum. In 1962, cantharidin lost Food and Drug
Rolf Rauh et al.
Chinese medicine, 2, 8-8 (2007-07-06)
Herbal medicine is one of the forms of traditional medical practice. Traditional Chinese medicine (TCM) and traditional Vietnamese medicine (TVM) are well-known for their long-standing tradition of herbal medicine. Secreted by many species of blister beetle, most notably by the

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