SML0204

MS-1020

≥98% (HPLC)

• 同義詞: 1-Hydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-naphtamide, 1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide
• 經驗公式（希爾表示法）: C₂₁H₁₈N₂O₃
• CAS號碼: 1255516-86-9
• 分子量：: 346.38
• 分類程式碼代碼: 12352202
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to tan
• 溶解度: DMSO: ≥10 mg/mL at 60 °C
• 儲存溫度: 2-8°C

描述

應用

MS-1020 may be used in JAK-3-mediated cell signaling studies.

生化／生理作用

MS-1020 is a selective JAK3 inhibitor

MS-1020 is an ATP-competitive, selective inhibitor of JAK3, thereby blocking downstream STAT signaling. MS-1020 binds directly with JAK3, blocking its catalytic activity. It suppressed IL-2-induced JAK3/STAT5 signaling but not prolactin-induced JAK2/STAT5 signaling. MS-1020 has also been shown to decreases cell survival by inducing apoptosis via downregulating anti-apoptotic gene expression.

特點和優勢

This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H319
• 防範說明: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable