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L8912

Sigma-Aldrich

L-亮氨酸

98.5-101.0%, suitable for cell culture, non-animal source, meets EP, JP, USP testing specifications

同義詞:

(S)-亮氨酸, (S)-2-氨基-4-甲基戊酸

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About This Item

線性公式:
(CH3)2CHCH2CH(NH2)CO2H
CAS號碼:
分子量::
131.17
Beilstein:
1721722
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.26
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產品名稱

L-亮氨酸, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%

生物源

non-animal source

agency

USP/NF
meets EP testing specifications
meets JP testing specifications
meets USP testing specifications

化驗

98.5-101.0%

形狀

powder

光學活性

[α]20/D 14.9 to 16.0°, c = 4 in 6 M HCl
[α]25/D 14.9 to 17.3 °, c = 4 in 6 M HCl

品質

meets EP, JP, USP testing specifications

技術

cell culture | mammalian: suitable

雜質

endotoxin, tested

顏色

white

mp

>300 °C (lit.)

溶解度

1 M HCl: 50 mg/mL

正離子痕跡

As: ≤1 ppm
Fe: ≤10 ppm
NH4+: <0.02%
heavy metals: ≤10 ppm

應用

peptide synthesis
pharmaceutical (small molecule)

官能基

amine
carboxylic acid

儲存溫度

room temp

SMILES 字串

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI 密鑰

ROHFNLRQFUQHCH-YFKPBYRVSA-N

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一般說明

亮氨酸是一种非生糖必需氨基酸。它是一种支链氨基酸,是蛋白质的结构组分。[1]

應用

L-亮氨酸可用于:

  • 作为肥大剂来监测其对肌管的影响。[2]
  • 作为培养酵母的 PMG 培养基的组成部分。[3]
  • 用于骨骼肌细胞的肌管蛋白质合成分析。[4]
  • 研究其对肝脏脂质代谢的影响。[5]

生化/生理作用

亮氨酸在细胞内信号转导、基因转录和翻译中发挥作用。它通过激活胎盘细胞、骨骼肌和脂肪组织中雷帕霉素(mTOR)信号通路的哺乳动物靶点来促进蛋白质的合成。[6]亮氨酸抑制蛋白质降解,促进线粒体生物合成、葡萄糖代谢和脂肪酸氧化,为蛋白质合成提供能量。[1]

其他說明

如需了解生化试剂系列的更多信息,请填写此表
本品仅供实验室使用,不适用于药物、家庭或其他用途。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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