暫時無法取得訂價和供貨情況
推薦產品
產品名稱
PP2, PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC₅₀ = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively).
品質等級
化驗
≥95% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
顏色
off-white
溶解度
DMSO: 20 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
SMILES 字串
Clc1ccc(cc1)c2n[n](c3ncnc(c32)N)C(C)(C)C
InChI
1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
InChI 密鑰
PBBRWFOVCUAONR-UHFFFAOYSA-N
一般說明
蛋白酪氨酸激酶Src家族的一种有效、可逆、ATP竞争性和选择性抑制剂。抑制p56lck （IC50=4 nM），p59fynT（IC50=5 nM），Hck（IC50=5 nM）和Src（IC50=100 nM）。不会显著影响EGFR激酶（IC50=480 nM），JAK2（IC50 >50 µM）或ZAP-70（IC50 >100 µ M）的活性。抑制黏着斑激酶的活化及其在Tyr577位点的磷酸化。还有效抑制人T细胞的抗CD3刺激的酪氨酸磷酸化（IC50=600 nM）。也可购买10 mM（1 mg/331 µl）PP2 （目录号529576）DMSO溶液。
生化／生理作用
主要靶标
p56lck
p56lck
产物与ATP竞争。
可逆性：是
细胞渗透性：否
靶标IC50：针对p56lck，p59fynT，Hck和Src分别为4 nM，5 nM，5 nM，100 nM；人T细胞的CD3刺激的酪氨酸磷酸化为600 nM
包裝
用惰性气体包装
警告
毒性：标准处理（A）
準備報告
仅在使用前再用水相缓冲液进行稀释。
其他說明
Karni, R., et al. 2003.FEBS Lett.537, 47.
Salazar, E.P., and Rozengurt, E. 1999.J. Biol. Chem. 274, 28371.
Hanke, J.H., et al. 1996.J. Biol. Chem.271, 695.
Selected Citations
Lee, J., et al. 2009.Cell Stem Cell5, 76.
Salazar, E.P., and Rozengurt, E. 1999.J. Biol. Chem. 274, 28371.
Hanke, J.H., et al. 1996.J. Biol. Chem.271, 695.
Selected Citations
Lee, J., et al. 2009.Cell Stem Cell5, 76.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
客戶也查看了
Claudin-4-adhesion signaling drives breast cancer metabolism and progression via liver X receptor β.
Yuko Murakami-Nishimagi et al.
Breast cancer research : BCR, 25(1), 41-41 (2023-04-15)
Cell adhesion is indispensable for appropriate tissue architecture and function in multicellular organisms. Besides maintaining tissue integrity, cell adhesion molecules, including tight-junction proteins claudins (CLDNs), exhibit the signaling abilities to control a variety of physiological and pathological processes. However, it
Elliot Dine et al.
Cell reports, 35(12), 109280-109280 (2021-06-24)
Protein clustering is pervasive in cell signaling, yet how signaling from higher-order assemblies differs from simpler forms of molecular organization is still poorly understood. We present an optogenetic approach to switch between oligomers and heterodimers with a single point mutation.
Emily C Suter et al.
Cell reports, 36(8), 109587-109587 (2021-08-26)
Cancer immunotherapies often modulate macrophage effector function by introducing either targeting antibodies that activate Fcγ receptors (FcγRs) or blocking antibodies that disrupt inhibitory SIRPα-CD47 engagement. However, how these competing signals are integrated is poorly understood, raising questions about how to
Zahra Alvandi et al.
Methods in molecular biology (Clifton, N.J.), 2520, 261-264 (2021-10-07)
Embryonic stem cells (ESCs) are a unique model that allows the study of molecular pathways underlying commitment and differentiation. We have studied signaling pathways and their contributions to osteogenic differentiation. In addition to our previously published protocol where we recommended
Quanri Zhang et al.
Experimental & molecular medicine, 50(2), e439-e439 (2018-02-06)
During mycobacteria infection, anti-inflammatory responses allow the host to avoid tissue damage caused by overactivation of the immune system; however, little is known about the negative modulators that specifically control mycobacteria-induced immune responses. Here we demonstrate that integrin CD11b is
Active Filters
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務
