SML0187

CJ-13610

≥98% (HPLC)

• 同義詞: Tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide
• 經驗公式（希爾表示法）: C₂₂H₂₃N₃O₂S
• CAS號碼: 179420-17-8
• 分子量：: 393.50
• MDL號碼: MFCD00948114
• 分類程式碼代碼: 51111800
• PubChem物質ID: 329825216
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to tan
• 溶解度: DMSO: ≥10 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: Cc1nccn1-c2ccc(Sc3cccc(c3)C4(CCOCC4)C(N)=O)cc2
• InChI: 1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26)
• InChI 密鑰: VPTONMHDLLMOOV-UHFFFAOYSA-N

描述

應用

CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.

生化／生理作用

CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC₅₀ = 70 nM).

CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice.[1]

Potent 5-lipoxygenase inhibitor

特點和優勢

This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable