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Merck
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重要文件

SCP0148

Sigma-Aldrich

Furin Inhibitor II Peptide

≥95% (HPLC), lyophilized powder

同義詞:

六-D-精氨酸酰胺

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About This Item

經驗公式（希爾表示法）:
C36H75N25O6
分子量：:
954.14
分類程式碼代碼:
12352202
NACRES:
NA.32
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產品名稱

弗林蛋白酶抑制剂 II,

化驗

≥95% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥48%

儲存條件

protect from light

技術

protein extraction: suitable

儲存溫度

−20°C

Amino Acid Sequence

Mpa-Mpa-Mpa-Mpa-Mpa-Mpa

一般說明

弗林蛋白酶是一种钙依赖性丝氨酸内蛋白酶，属于枯草杆菌蛋白酶样前蛋白/激素转换酶（PC）家族。[1]它分布广泛，并且可在反式高尔基网络、细胞表面和内体之间有节规律的移动。[1]

應用

弗林蛋白酶抑制剂II已作为弗林蛋白酶抑制剂用于：
  • 研究在非致瘤性永生化人类颗粒细胞系（SVOG）中，其对转化生长因子β1（TGF-β1） 诱导的神经胶质细胞系衍生的神经营养因子（GDNF）产生的影响。[2]
  • 研究其对人肾2（HK-2）细胞中牛血清白蛋白（BSA）诱导的肾素（原）受体（PRR）裂解的作用。[3]
  • 用于弗林蛋白酶裂解试验中。[4]

生化／生理作用

弗林蛋白酶在几种前蛋白的加工中起作用，例如骨形态发生蛋白4（BMP-4）、胰岛素受体和Notch1受体。它还可以处理人类免疫缺陷病毒1（HIV-1）糖蛋白gp160、几种金属蛋白酶、以及β-神经增长因子前体（β-NGF前体）。弗林蛋白酶还可参与转化生长因子 β1（TGF-β1）的裂解。[5]

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number
E278093
E257140
E1094
MI1170

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Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme
Dubois C M, et al.
The American Journal of Pathology, 158(1), 305-316 (2001)
A Cameron et al.
The Journal of biological chemistry, 275(47), 36741-36749 (2000-08-26)
The ubiquitous serine endoprotease furin has been implicated in the activation of bacterial toxins and viral glycoproteins as well as in the metastatic progression of certain tumors. Although high molecular mass bioengineered serpin inhibitors have been well characterized, no small
Marcel Westenberg et al.
Journal of virology, 76(1), 178-184 (2001-12-12)
The Spodoptera exigua multicapsid nucleopolyhedrovirus (SeMNPV) Se8 gene was recently shown to encode the viral envelope fusion (F) protein. A 60-kDa C-terminal subunit (F1) of the 76-kDa primary translation product of this gene was found to be the major envelope
Miroslav S Sarac et al.
Infection and immunity, 70(12), 7136-7139 (2002-11-20)
The Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity. We show here that the small stable furin inhibitor hexa-D-arginine amide effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-D-arginine to PEA-treated mice
Miroslav S Sarac et al.
Infection and immunity, 72(1), 602-605 (2003-12-23)
The anthrax toxin protective antigen precursor is activated by proteolytic cleavage by furin or a furin-like protease. We present here data demonstrating that the small stable furin inhibitor hexa-D-arginine amide delays anthrax toxin-induced toxemia both in cells and in live
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Questions

1–3 of 3 Questions  

  1. How can product SCP0148, Furin Inhibitor II, be dissolved?

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    1. Product SCP0148, Furin Inhibitor II is soluble in water at 1 mg/ml.

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  2. What is the Department of Transportation shipping information for this product?

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    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  3. How can Product SCP0148, Furin Inhibitor II be dissolved?

    1 answer

    1. Product SCP0148, Furin Inhibitor II, is soluble in water at a concentration of 1 mg/mL.

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