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Merck
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重要文件

SAB5300406

Sigma-Aldrich

Monoclonal Anti-PBK antibody produced in mouse

clone 2C8, ascites fluid

同義詞:

CT84, Nori-3, SPK, TOPK

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

共軛

unconjugated

抗體表格

ascites fluid

抗體產品種類

primary antibodies

無性繁殖

2C8, monoclonal

分子量

36 kDa

物種活性

human

技術

direct ELISA: 1:10,000
flow cytometry: 1:200-1:400
immunohistochemistry: 1:200-1:1,000
indirect immunofluorescence: 1:200-1:1,000
western blot: 1:500-1:2,000

同型

IgG2b

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... PBK(55872)

免疫原

Purified recombinant fragment of human PBK expressed in E.coli.
Mouse monoclonal antibody raised against PBK

外觀

Ascitic fluid containing 0.03% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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Giacomo Pirovano et al.
Molecular imaging and biology, 21(4), 705-712 (2018-10-26)
Lymphokine-activated killer T cell-originated protein kinase (TOPK) is a fairly new cancer biomarker with great potential for clinical applications. The labeling of a TOPK inhibitor with F-18 can be exploited for positron emission tomography (PET) imaging allowing more accurate patient
Giacomo Pirovano et al.
European journal of nuclear medicine and molecular imaging, 47(4), 1003-1010 (2019-11-18)
OTS514 is a highly specific inhibitor targeting lymphokine-activated killer T cell-originated protein kinase (TOPK). A fluorescently labeled TOPK inhibitor could be used for tumor delineation or intraoperative imaging, potentially improving patient care. Fluorescently labeled OTS514 was obtained by conjugating the
Katharine J Herbert et al.
Cell death and differentiation, 28(4), 1333-1346 (2020-11-11)
T-LAK-originated protein kinase (TOPK) overexpression is a feature of multiple cancers, yet is absent from most phenotypically normal tissues. As such, TOPK expression profiling and the development of TOPK-targeting pharmaceutical agents have raised hopes for its future potential in the
Giacomo Pirovano et al.
British journal of cancer, 117(4), 503-512 (2017-07-06)
Tumour-specific radiosensitising treatments may enhance the efficacy of radiotherapy without exacerbating side effects. In this study we determined the radiation response following depletion or inhibition of TOPK, a mitogen-activated protein kinase kinase family Ser/Thr protein kinase that is upregulated in

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