推薦產品
化驗
≥98% (HPLC)
形狀
solid
顏色
white
溶解度
DMSO: ~6 mg/mL
H2O: insoluble
儲存溫度
2-8°C
SMILES 字串
C1COc2c(O1)cccc2N3CCN(CC3)C4Cc5ccccc5C4
InChI
1S/C21H24N2O2/c1-2-5-17-15-18(14-16(17)4-1)22-8-10-23(11-9-22)19-6-3-7-20-21(19)25-13-12-24-20/h1-7,18H,8-15H2
InChI 密鑰
QJPPEMXOOWNICQ-UHFFFAOYSA-N
應用
S15535 has been used as a serotonin 1A receptor (5-HT1A) agonist in zebrafish.[1]
S15535 may be used in histamine 5-HT1A-medaited cell signaling studies.
生化／生理作用
Potent, orally active, partial 5-HT1A receptor agonist
S15535, a benzodioxane, is a selective but partial agonist of histamine serotonin 1A (5-HT1A) receptor. It activates presynaptic 5-HT1A receptors and suppresses the release of hippocampal 5-HT. It acts as an anxiolytic agent and modulates the cholinergic and cognitive function in rodents.[2]
訊號詞
Warning
危險聲明
危險分類
Aquatic Acute 1 - Aquatic Chronic 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves
A Newman-Tancredi et al.
Neuropharmacology, 36(4-5), 451-459 (1997-04-01)
Membrane preparations were made from Chinese Hamster Ovary (CHO) cells expressing 1.6 and 4.2 pmol/mg of recombinant human 5-HT1A receptors, as determined by saturation binding with the selective antagonist, [3H]-S 15535 ([3H]-4-(benzodioxan-5-yl)]-(indan-2-yl)piperazine). There was no change in the number of
A Newman-Tancredi et al.
European journal of pharmacology, 307(1), 107-111 (1996-06-20)
In Chinese hamster ovary (CHO) cells expressing cloned human 5-HT1A receptors, S 15535 (4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine) exhibited high affinity (Ki = 0.79 nM), similar to that of 5-HT (0.61 nM), (+/-)-8-hydroxy-3-(di-n-propylamino)tetralin ((+/-)-8-OH-DPAT; 0.58 nM) and N-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-N- (2-pyridinyl)cyclo-hexanecarboxamide (WAY 100.635; 0.56 nM). In
Jiun Youn et al.
Neuropharmacology, 57(5-6), 567-576 (2009-07-18)
5-HT(1A) receptors are implicated in the modulation of cognitive processes including encoding of fear learning. However, their exact role has remained unclear due to contrasting contributions of pre- vs. postsynaptic 5-HT(1A) receptors. Therefore, their role in fear conditioning was studied
R L Gannon et al.
Neuroscience, 137(1), 287-299 (2005-11-18)
Mammalian circadian activity rhythms are generated by pacemaker cells in the suprachiasmatic nucleus (SCN). As revealed by the actions of diverse agonists, serotonergic input from raphe nuclei generally inhibits photic signaling in the suprachiasmatic nucleus. In contrast, the serotonin (5HT)1A
Mark J Millan et al.
The Journal of pharmacology and experimental therapeutics, 311(1), 190-203 (2004-05-18)
These studies examined the influence of the selective 5-hydroxytryptamine (serotonin) (5-HT)(1A) receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] upon cholinergic transmission and cognitive function in rodents. In the absence of acetylcholinesterase inhibitors, S15535 dose-dependently (0.04-5.0 mg/kg s.c.) elevated dialysis levels of acetylcholine
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