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S4881

Sigma-Aldrich

葡萄球菌肠毒素B 来源于金黄色葡萄球菌

同義詞:

SEB, 肠毒素B,葡萄球菌

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About This Item

CAS號碼:
MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.25
暫時無法取得訂價和供貨情況

包含

sodium phosphate buffer as balance

品質等級

成份

Protein, ~25% Lowry

存貨情形

not available in USA

雜質

Staphylococcal enterotoxin A (SEA), essentially free

應用

metabolomics
vitamins, nutraceuticals, and natural products

儲存溫度

2-8°C

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應用

与 MHC II 类分子和 T 细胞受体(TCR)的特异性 Vβ 区结合的葡萄球菌肠毒素 B(SEB),可导致单核细胞/巨噬细胞和 T 淋巴细胞的激活,可用作超抗原和免疫系统激活剂。 SEB 可用作 SEB 检测系统开发中的参考材料。

生化/生理作用

T 淋巴细胞的超抗原。 与主要组织相容性复合体(MHC)抗原[1]和 CD28 结合的免疫系统激活剂。[2]

包裝

包装尺寸基于蛋白质含量。

相關產品

產品號碼
描述
訂價

象形圖

Skull and crossbones

訊號詞

Danger

危險分類

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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存取文件庫

Bacterial superantigens
Proft, T. and Fraser, J.D.
Clinical and Experimental Immunology, 133, 299-299 (2008)
Clarifying the mechanism of superantigen toxicity.
John D Fraser
PLoS biology, 9(9), e1001145-e1001145 (2011-09-21)
Winnie Bergstedt et al.
PloS one, 5(6), e11277-e11277 (2010-07-02)
Tuberculin is still the only available skin test reagent for the diagnosis of mycobacterial infection. The product has a remarkable sensitivity, but poor specificity. Previous studies, including two human phase I clinical trials, have indicated that rdESAT-6 has a potential
Oliver G Weingart et al.
Sensors (Basel, Switzerland), 12(2), 2324-2339 (2012-03-23)
Prevalent incidents support the notion that toxins, produced by bacteria, fungi, plants or animals are increasingly responsible for food poisoning or intoxication. Owing to their high toxicity some toxins are also regarded as potential biological warfare agents. Accordingly, control, detection
Philippe O Gannon et al.
Cytotherapy, 22(12), 780-791 (2020-10-19)
Several studies report on Good Manufacturing Process (GMP)-compliant manufacturing protocols for the ex vivo expansion of tumor-infiltrating lymphocytes (TILs) for the treatment of patients with refractory melanoma and other solid malignancies. Further opportunities for improvements in terms of ergonomy and

Questions

1–4 of 4 Questions  
  1. What is the difference in effects on T-lymphocyte proliferation between PHA and SEB? Thank you

    1 answer
    1. T-cells stimulated with SEB produce high levels of IFN-γ, while PHA-stimulated T-cells produce little or no IFN-γ. For more information, refer to the reference at the following link: https://pmc.ncbi.nlm.nih.gov/articles/PMC1906565/#:~:text=%2Dcells%20(Fig.-,1).,compared%20to%20CD4+%20T%2Dcells

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  4. こんにちは、この商品の容量をお聞きしたいのですが、1MGと表記されている場合、1miligramということでしょうか? 溶かしてから調剤したいのですが。 溶かして調剤する際のプロトコルはあるのでしょうか?

    1 answer
    1. Yes, the 1MG does stand for one milligram. The product is soluble in water at 4 mg/ml. It may also be dissolved in an aqueous buffer such as PBS. See the link below to the product information sheet for additional solution stability information:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/126/857/s4881pis.pdf

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