As mentioned in the 'PROPERTIES' section, this product can be solubilized in chloroform at 50 mg/mL. In addition, this material is also soluble in DMSO at 5 mg/mL. DMSO stock solutions are stable for at least 6 months at -20°C. Please see the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/140/282/r7772pis.pdf
推薦產品
生物源
synthetic (organic)
化驗
≥98% (TLC)
形狀
powder
mp
106-107 °C
溶解度
chloroform: 50 mg/mL, clear, colorless to light yellow
儲存溫度
−20°C
SMILES 字串
CC[C@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1
InChI
1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
InChI 密鑰
BTIHMVBBUGXLCJ-OAHLLOKOSA-N
基因資訊
human ... CDK1(983) , CDK2(1017) , CDK5(1020) , CDK7(1022) , CDK9(1025) , CDKN1A(1026) , CDKN1B(1027) , CDKN1C(1028) , CDKN2A(1029) , CDKN2B(1030) , CDKN2C(1031) , CDKN2D(1032) , CDKN3(1033)
mouse ... CDK1(12534)
rat ... CDK1(54237)
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應用
生化／生理作用
Roscovitine是一种嘌呤衍生的抑制剂。它可刺激癌细胞的凋亡，[5]对有丝分裂原活化蛋白激酶（MAPK）和M期促进因子（MPF）激酶活性具有抑制作用。Roscovitine已知可阻止减数分裂，从而阻止胚胎发育。[2]
核抑制剂是细胞周期蛋白依赖性激酶的一种有效的、选择性抑制剂。
特點和優勢
该化合物是细胞凋亡研究的推荐产品。点击此处了解更多特色细胞凋亡产品。在sigma.com/discover-bsm 上了解有关生物活性小分子在其他研究领域的更多信息。
法律資訊
经 CNRS 许可销售
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
從最近期的版本中選擇一個：
分析證明 (COA)
Lot/Batch Number
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In what solvent and at what concentration do I reconstitute Roscovitine (R7772) ?
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