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Merck
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文件

O0886

Sigma-Aldrich

奥罗莫星

≥98% (HPLC)

同義詞:

2-(羟基乙基氨基)-6-苄基氨基-9-甲基嘌呤

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About This Item

經驗公式（希爾表示法）:
C15H18N6O
CAS號碼:
101622-51-9
分子量：:
298.34
MDL號碼:
MFCD00189360
分類程式碼代碼:
12352200
PubChem物質ID:
24278053
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

溶解度

DMSO: 20 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12

InChI

1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)

InChI 密鑰

GTVPOLSIJWJJNY-UHFFFAOYSA-N

基因資訊

human ... CDC2(983) , CDK2(1017) , CDK3(1018) , CDK4(1019) , CDK5(1020) , CDK6(1021) , CDK7(1022) , CDK8(1024) , CDK9(1025) , CDKN1A(1026) , CDKN1B(1027) , CDKN1C(1028) , CDKN2A(1029) , CDKN2B(1030) , CDKN2C(1031) , CDKN2D(1032) , CDKN3(1033)
rat ... Prkca(24680)

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生化／生理作用

Olomoucine 是一种嘌呤衍生物，可抑制细胞周期蛋白依赖性激酶并诱导 G 阻滞。

特點和優勢

《受体分类和信号转导》手册的 CDK 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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R T Abraham et al.
Biology of the cell, 83(2-3), 105-120 (1995-01-01)
Olomoucine (2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine) has been recently described as a competitive inhibitor (ATP-binding site) of the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cyclin A and p33cdk2/cyclin E kinases, the brain p33cdk5/p35 kinase and the ERK1/MAP-kinase. The unusual specificity of this compound towards cell
J Veselý et al.
European journal of biochemistry, 224(2), 771-786 (1994-09-01)
While testing purines related to the non-specific protein kinase inhibitors N6-dimethylaminopurine and N6-(delta 2-isopentenyl)adenine as potential inhibitors of the p34cdc2/cyclin B kinase, we discovered a compound with high specificity, 2-(2-hydroxyethylamino)-6- benzylamino-9-methylpurine (olomoucine). Kinetic analysis of kinase inhibition reveals that olomoucine
Wei Mao et al.
Journal of experimental & clinical cancer research : CR, 31, 49-49 (2012-05-25)
Gastrokine-1 (GKN1), a secreted protein, is specifically expressed in gastric mucosa to protect and maintain the integrity of gastric epithelium. The present study investigated differential expression of GKN1 in normal, precancerous, and cancerous gastric tissues, and explored the biological functions
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Molecular vision, 14, 542-549 (2008-04-04)
To investigate the effect of the Cdk5 inhibitor olomoucine on corneal debridement wound healing in vivo. Corneal debridement wounds of 1.5 mm were made on the ocular surface of CD-1 mice. A 20 microl drop of 15 microM olomoucine in
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Extracellular molecular cues guide migrating growth cones along specific routes during development of axon tracts. Such processes rely on asymmetric elevation of cytosolic Ca(2+) concentrations across the growth cone that mediates its attractive or repulsive turning toward or away from

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

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