R1656
RAF1 (EE) (306-end), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
同義詞:
CMD1NN, NS5, RAF proto-oncogene serine/threonine-protein kinase, cRaf
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About This Item
分類程式碼代碼:
12352200
NACRES:
NA.32
暫時無法取得訂價和供貨情況
推薦產品
生物源
fermentation/recombinant
品質等級
重組細胞
expressed in baculovirus infected Sf9 cells
產品線
PRECISIO® Kinase
化驗
≥70% (SDS-PAGE)
形狀
buffered aqueous glycerol solution
比活性
5100-6900 nmol/min·mg
分子量
~63 kDa
製造商／商標名
Precision
技術
cell based assay: suitable
溶解度
water: soluble
Protein ID登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... RAF1(5894)
一般說明
Research area: Cell Signaling
Rapidly Accelerated Fibrosarcoma (RAF) belongs to receptor tyrosine kinase (RTK) family. RAF exists as three isoforms A, B and C-RAF or RAF-1. [1] RAF1 links Ras family members with mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling cascade.[2] The RAF-1 gene is mapped to the human chromosome at 3p25.2.[3]
Rapidly Accelerated Fibrosarcoma (RAF) belongs to receptor tyrosine kinase (RTK) family. RAF exists as three isoforms A, B and C-RAF or RAF-1. [1] RAF1 links Ras family members with mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling cascade.[2] The RAF-1 gene is mapped to the human chromosome at 3p25.2.[3]
生化／生理作用
Rapidly Accelerated Fibrosarcoma 1(RAF1), a member of MAP kinase kinase kinase (MAP3K) family plays a vital role in cell signaling by directly interacting with GTPases and functions downstream in their signaling pathway.[4] RaF1 is activated by Ras in the presence of growth-promoting signals, leading to the activation of mitogen-activated protein kinase kinase (MEK1/MEK2) and extracellular signal-regulated protein kinases 1 and 2 (ERK1/ERK2) downstream. [5] The activated ERK proteins control gene expression related to cell division, apoptosis, cell differentiation, and cell migration.[4] The gene is mutated or upregulated in prostate and bladder cancer.[5] Also, mutations are associated with Noonan syndrome, which leads to various physical abnormalities like craniofacial dysmorphisms, ocular, and musculoskeletal irregularities, neurocognitive impairment, and cardiac malformations.[4]
外觀
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律資訊
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
Wong S, et al.
EMBO Molecular Medicine, 15(5), e17078-e17078 (2023)
Benjamin R Nixon et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 1138-1150 (2018-08-15)
Raf1/c-Raf is a well-characterized serine/threonine-protein kinase that links Ras family members with the MAPK/ERK signaling cascade. We have identified a novel splice isoform of human Raf1 that causes protein truncation and loss of the C-terminal kinase domain (Raf1-tr). We found
Raf kinases: function, regulation and role in human cancer
Leicht DT, et al.
Biochimica et Biophysica Acta, 1773(8), 1196-1212 (2007)
Vertical pathway targeting in cancer therapy
Shahbazian D, et al.
Advances in Pharmacology, 65, 1-26 (2012)
Olafur Andri Stefansson et al.
Breast cancer research : BCR, 13(3), 309-309 (2011-06-16)
Members of the Polycomb-group (PcG) family of proteins, including EZH2 (enhancer of zeste homolog 2), are involved in establishing epigenetic silencing of developmental genes in adult and embryonic stem cells, and their deregulation has been implicated in cancer. In a
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