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About This Item
經驗公式（希爾表示法）:
C13H13N3 · C4H6O6
CAS號碼:
分子量：:
361.35
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: >5 mg/mL
儲存溫度
room temp
SMILES 字串
O[C@H]([C@@H](O)C(O)=O)C(O)=O.C1NC[C@H]2C[C@@H]1c3cc4nccnc4cc23
InChI
1S/C13H13N3.C4H6O6/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1;5-1(3(7)8)2(6)4(9)10/h1-2,4-5,8-9,14H,3,6-7H2;1-2,5-6H,(H,7,8)(H,9,10)/t8-,9+;1-,2-/m.1/s1
InChI 密鑰
TWYFGYXQSYOKLK-CYUSMAIQSA-N
應用
酒石酸伐伦克林已被用于研究其在预脉冲抑制（PPI）下对大鼠感觉运动门控的作用。 它适合用作参考标准品，通过毛细管等速电泳（ITP）和毛细管区带电泳（CZE）在线耦合对尿液样本中的伐伦克林代谢产物进行定量。 它也适用于测试其对大鼠运动和非运动行为缺陷的作用。
生化／生理作用
酒石酸伐伦克林是一种部分α4β2烟碱样受体激动剂和α7完全激动剂。伐伦克林可竞争性地与α4β2受体结合，并在不产生完全尼古丁效应的情况下进行部分刺激，同时阻断尼古丁与受体结合的能力。因此，伐伦克林可阻断尼古丁激活α4β2受体并刺激中枢中脑边缘多巴胺系统的能力，这被认为是吸烟后增强和获得奖赏的神经元机制。
特點和優勢
该化合物在受体分类和信号转导手册的乙酰胆碱受体（烟碱型）页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Aquatic Acute 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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文章
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Sigma-Aldrich offers many products related to nicotinic acetylcholine receptors for your research needs.
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