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Merck
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重要文件

P9403

Sigma-Aldrich

poly(A)

同義詞:

聚腺苷酸 钾盐, Poly(A) 钾盐

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About This Item

CAS號碼:
MDL號碼:
分類程式碼代碼:
41106305
NACRES:
NA.51
暫時無法取得訂價和供貨情況

形狀

powder

品質等級

儲存溫度

−20°C

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應用

聚腺苷酸(poly-A)用于评估掺杂有非离子型核脂的阳离子脂质体上的结合情况。 在小分子mRNA靶向药物的开发中,Poly-A用于评估潜在药物(如异喹啉类生物碱)的结合情况。

準備報告

用多核苷酸磷酸化酶由ADP制备

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Polyadenylic acid binding on cationic liposomes doped with the non-ionic nucleolipid Lauroyl Uridine.
Cuomo F, Ceglie A, Colafemmina G, et al.
Colloids and Surfaces, B: Biointerfaces, 82, 277-282 (2011)
Prabal Giri et al.
Molecular bioSystems, 6(1), 81-88 (2009-12-22)
The use of small molecules to specifically control important cellular functions through binding to nucleic acids is an area of major current interest at the interface of chemical biology and medicinal chemistry. The polyadenylic acid [poly(A)] tail of mRNA has
Prabal Giri et al.
Current medicinal chemistry, 16(8), 965-987 (2009-03-12)
The use of small molecules to specifically control important cellular functions is an area of major current interest at the interface of chemical biology and medicinal chemistry. Recognition of ribonucleic acids (RNA) has emerged more recently as a critical event
Tian-Li Duan et al.
Cells, 8(8) (2019-08-08)
Poly(A)-specific ribonuclease (PARN), a multifunctional multi-domain deadenylase, is crucial to the regulation of mRNA turnover and the maturation of various non-coding RNAs. Despite extensive studies of the well-folding domains responsible for PARN catalysis, the structure and function of the C-terminal
Costas Delis et al.
RNA biology, 13(1), 68-82 (2015-12-01)
We report the identification and characterization of a novel gene, AtHesperin (AtHESP) that codes for a deadenylase in Arabidopsis thaliana. The gene is under circadian clock-gene regulation and has similarity to the mammalian Nocturnin. AtHESP can efficiently degrade poly(A) substrates

Questions

1–2 of 2 Questions  
  1. What about the nucleotide length? How many mers of Adenine connected?

    1 answer
    1. This product is not tested for molecular weight or chain length. However, historical data suggests a range of 300 - 4400 bases with a molecular weight range of 128,000 - 1,900,000 daltons, respectively.

      Helpful?

  2. Which solvent is best for reconstituting poly A?

    1 answer
    1. The product P9403 is soluble in water to 20 mg/ml.

      Helpful?

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