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重要文件

P1793

Sigma-Aldrich

匹莫齐特

≥98% (TLC), powder, D₂ dopamine receptor antagonist

同義詞:

1-[1-[4,4-双(4-氟苯基)丁基]-4-哌啶基]-1,3-二氢-2H-苯并咪唑-2-酮

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About This Item

經驗公式(希爾表示法):
C28H29F2N3O
CAS號碼:
分子量::
461.55
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

產品名稱

匹莫齐特,

形狀

powder

溶解度

DMSO: 18 mg/mL(lit.)
chloroform: 5 mg/mL
H2O: insoluble(lit.)

起源

Teva

儲存溫度

2-8°C

SMILES 字串

Fc1ccc(cc1)C(CCCN2CCC(CC2)N3C(=O)Nc4ccccc34)c5ccc(F)cc5

InChI

1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)

InChI 密鑰

YVUQSNJEYSNKRX-UHFFFAOYSA-N

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生化/生理作用

D 2 多巴胺受体拮抗剂;与克隆的 5-HT 7 受体高亲和力结合;Ca 2 + 通道拮抗剂;抗精神病药

特點和優勢

该化合物在受体分类和信号转导手册的环核苷酸门控(CNG)和超极化激活的环核苷酸门控(HCN)通道页面上有详细描述。想要浏览手册的其他页面, 请单击此处
该化合物是环核苷酸研究的特色产品。 点击此处 ,发现更多特色环核苷酸产品。。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
该化合物由 Teva 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表,请点击此处

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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Holger H H Erb et al.
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Despite enzalutamide's efficacy in delaying the progression of metastatic castration-resistant prostate cancer (CRPC), resistance to this anti-androgen inevitably occurs. Several studies have revealed that the signal transducer and activator of transcription (STAT) 5 plays a role in tumour progression and
Junjun Chen et al.
Chemistry & biology, 18(11), 1390-1400 (2011-11-29)
Ubiquitin-specific proteases (USPs) have in recent years emerged as a promising therapeutic target class. We identified selective small-molecule inhibitors against a deubiquitinase complex, the human USP1/UAF1, through quantitative high throughput screening (qHTS) of a collection of bioactive molecules. The top
Erik A Nelson et al.
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The transcription factor STAT5 is an essential mediator of the pathogenesis of chronic myelogenous leukemia (CML). In CML, the BCR/ABL fusion kinase causes the constitutive activation of STAT5, thereby driving the expression of genes promoting survival. BCR/ABL kinase inhibitors have
L A Opler et al.
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Pimozide, a diphenylbutylpiperidine neuroleptic which is FDA-approved as a backup treatment for Gilles de la Tourette's syndrome, has been used abroad for many years as a treatment of schizophrenia and has been recently reported to be particularly effective in treating
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Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs approved for other human diseases could be

文章

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Questions

  1. When dissolved in DMSO, at what temperature should I store the solution?

    1 answer
    1. The storage temperature and solution stability after reconstitution in DMSO have not been tested. It is recommended to make the solution fresh upon usage.

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