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重要文件

O9389

Sigma-Aldrich

奥替普拉

≥98% (HPLC), powder

同義詞:

1,2-二硫杂环戊烷-3-硫酮, BRN 0978110, CCRIS 4048, NSC 347901, RP 35972

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About This Item

經驗公式(希爾表示法):
C8H6N2S3
CAS號碼:
分子量::
226.34
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

化驗

≥98% (HPLC)

形狀

powder

儲存條件

protect from light

顏色

red

溶解度

DMSO: >20 mg/mL

儲存溫度

2-8°C

SMILES 字串

CC1=C(SSC1=S)c2cnccn2

InChI

1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3

InChI 密鑰

CKNAQFVBEHDJQV-UHFFFAOYSA-N

一般說明

Oltipraz是一种二硫醇衍生物,是二硫代硫酮类有机硫化合物的成员。它具有抗肿瘤,抗氧化,抗炎和放射防护的特性。[1][2] 可以抵抗多种致癌物。[3]Oltipraz可以用作抗血吸虫药。[1]

生化/生理作用

Oltipraz 是 Nrf2 的激活剂。
Oltipraz是Nrf2的激活剂。 Nrf2(NF-E2相关因子2)是一种转录因子,可与抗氧化反应元件(ARE) 结合并激活这些基因。 Oltipraz可激活Nrf2,随后提高编码抗氧化剂和多药耐药相关蛋白的解毒基因的表达,以介导其化学预防功效。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

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存取文件庫

Alberto Izzotti et al.
Cancer prevention research (Philadelphia, Pa.), 3(1), 62-72 (2010-01-07)
We previously showed that exposure to environmental cigarette smoke (ECS) for 28 days causes extensive downregulation of microRNA expression in the lungs of rats, resulting in the overexpression of multiple genes and proteins. In the present study, we evaluated by
A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia
Lam S, et al.
Journal of the National Cancer Institute, 94(13), 1001-1009 (2002)
Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis
Iida K, et al.
Cancer Research, 64(18), 6424-6431 (2004)
Sang Geon Kim et al.
The Journal of pharmacy and pharmacology, 63(5), 627-635 (2011-04-16)
Oltipraz, a cancer chemopreventive agent, has an anticirrhotic effect in animals. A phase II trial was designed to investigate the preliminary efficacy of oltipraz therapy in liver fibrosis or cirrhosis. Of 83 patients who were randomized to receive placebo, oltipraz
The effects of oltipraz on tissue regeneration in the process of wound healing: a stereological study
Noorafshan A, et al.
Bulletin of emergency and trauma, 2(4), 161-161 (2014)

Questions

  1. What is the average shelf-life of this compound?

    1 answer
    1. Product O9389, Oltipraz, has no Retest or Expiration Date. There are a number of products with the only date shown on the lot-specific Certificate of Analysis being the Release Date. For these products there is no stated Retest, Expiration or Use-by-Date Date. We recommend handling per defined conditions as printed in our product literature and website product descriptions. Products should be routinely inspected by the customer to ensure they perform as expected.
      For those products, only our standard warranty of 1 year is applicable. For further information on our warranty please refer to terms and conditions of sale.

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