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About This Item
經驗公式（希爾表示法）:
C32H43NO4
CAS號碼:
分子量：:
505.69
MDL號碼:
分類程式碼代碼:
12352205
PubChem物質ID:
NACRES:
NA.25
推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
應用
metabolomics
vitamins, nutraceuticals, and natural products
儲存溫度
−20°C
SMILES 字串
CC1(C)CC[C@]2(C(OC)=O)CC[C@@]([C@@]3([H])[C@]2([H])C1)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O
InChI
1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
InChI 密鑰
WPTTVJLTNAWYAO-KPOXMGGZSA-N
基因資訊
human ... IKBKB(3551) , KEAP1(9817) , NFE2L2(4780) , PPARG(5468)
一般說明
CDDO-Me 是一种合成的三萜类化合物，具有抗炎、抗肿瘤和细胞保护作用。它来源于天然产物齐墩果酸。
應用
CDDO甲酯（甲基巴多索隆）已用于在肝脏缺血再灌注损伤(IRI)中检测其对肝细胞膜转运蛋白(HMT)的调控和对胆汁淤积症的缓解作用。它也作为NF E2相关因子2(NRF2)的激活剂，用于研究其防止黑色素瘤细胞死亡的作用。
生化／生理作用
CDDO-Me可抑制炎症介质，如白介素-6(IL-6)、IL-10和IL-12。它可增强TNF和化疗试剂诱导的细胞凋亡。CDDO-Me具有抗骨肉瘤细胞增殖活性，通过激活内源性线粒体依赖型细胞凋亡通路，可增强化疗试剂的有效性。它可作为进展型和致死型前列腺癌的辅助治疗手段。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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