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Merck
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重要文件

N4007

Sigma-Aldrich

N-Nitroso-N-methylbutylamine

同義詞:

Methylbutylnitrosamine

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About This Item

經驗公式(希爾表示法):
C5H12N2O
CAS號碼:
分子量::
116.16
MDL號碼:
分類程式碼代碼:
12352116
PubChem物質ID:
NACRES:
NA.25
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形狀

liquid

品質等級

密度

0.93 g/mL (lit.)

儲存溫度

2-8°C

SMILES 字串

CCCCN(C)N=O

InChI

1S/C5H12N2O/c1-3-4-5-7(2)6-8/h3-5H2,1-2H3

InChI 密鑰

PKTSCJXWLVREKX-UHFFFAOYSA-N

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包裝

散装

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險分類

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Carc. 1B

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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分析證明 (COA)

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E Suzuki et al.
Japanese journal of cancer research : Gann, 76(3), 184-191 (1985-03-01)
In order to compare the extents of metabolic alpha-hydroxylation of the two alkyl groups in unsymmetrical N-nitrosodialkylamines, N-nitroso-N-alkylbutylamines (alkyl = methyl, ethyl, propyl, butyl, and amyl) were incubated with liver microsomes prepared from phenobarbital- or polychlorinated biphenyl (PCB)-treated and untreated
B Ludeke et al.
IARC scientific publications, (105)(105), 286-293 (1991-01-01)
Aliphatic methylalkylnitrosamines with a chain length of three to six carbon atoms are powerful oesophageal carcinogens in rats and have been shown to methylate target organ DNA preferentially. This class of carcinogens is efficiently metabolized not only in the oesophageal
T Kawanishi et al.
Cancer letters, 20(2), 157-164 (1983-09-01)
The effect of phenobarbital (PB) and 3-methylcholanthrene (MC) pretreatment on dealkylations of N-nitrosodimethylamine (NDMA), N-nitrosomethylbutylamine (NMBuA) and N-nitrosomethylbenzylamine (NMBeA) was investigated in rat hepatic microsomes. PB increased the demethylation and the debutylation of NMBuA and the debenzylation of NMBeA. MC
W Lijinsky et al.
Carcinogenesis, 1(2), 157-160 (1980-02-01)
Nitrosomethyl-n-butylamine and its derivatives, labeled with deuterium in the methyl group or at the alpha position of the butyl group, were given to rats in drinking water at equimolar doses for approximately 20 weeks. Two concentrations were used, 16 mg/l
J G Farrelly et al.
Cancer research, 42(6), 2105-2109 (1982-06-01)
With the use of rat liver preparations, the in vitro microsomal metabolism of methylethylnitrosamine, methyl-n-butylnitrosamine, and methyl(2-phenylethyl)nitrosamine labeled with deuterium in the methyl and alpha-methylene positions has been compared with that of the parent (unlabeled) compounds. All three forms of

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