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重要文件

N0756

Sigma-Aldrich

N-亚硝基二乙胺

liquid, nitrosamine

同義詞:

二乙基亚硝胺

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About This Item

線性公式:
(C2H5)2NNO
CAS號碼:
分子量::
102.14
Beilstein:
1744991
EC號碼:
MDL號碼:
分類程式碼代碼:
12352116
PubChem物質ID:
NACRES:
NA.77
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產品名稱

N-亚硝基二乙胺, liquid

形狀

liquid

顏色

yellow

bp

177 °C (lit.)

密度

0.95 g/mL (lit.)

SMILES 字串

CCN(CC)N=O

InChI

1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3

InChI 密鑰

WBNQDOYYEUMPFS-UHFFFAOYSA-N

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一般說明

N-亚硝基二乙胺属于亚硝胺类含氮消毒副产物。用氯消毒的水处理设备中也能产生这种副产物。[1]

應用

N-亚硝基二乙胺已用于诱发大鼠[2][3]和小鼠的肝细胞癌发生。[4]

生化/生理作用

N-亚硝基二乙胺(NDMA)对于所有受试动物物种都是致癌物。主要靶器官是鼻腔、气管、肺、食道和肝脏。[5]NDMA通过作用于细胞色素P450系统而导致致癌物甲基重氮离子的产生。但假单胞菌等微生物可将NDMA代谢为N-硝基甲胺(NTMA)和甲醛。[6]

包裝

批量包装

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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分析證明 (COA)

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存取文件庫

Effects of heavy metal ions on N-nitrosodimethylamine (NDMA) formation
Liu Y, et al.
Royal Society of Chemistry Advances, 6(74), 70474-70479 (2016)
Jun Ho Lee et al.
EBioMedicine, 58, 102926-102926 (2020-08-03)
High recurrence and chemoresistance drive the high mortality in hepatocellular carcinoma (HCC). Although cancer stem cells are considered to be the source of recurrent and chemoresistant tumors, they remain poorly defined in HCC. Tonicity-responsive enhancer binding protein (TonEBP) is elevated
Smyd3 is a transcriptional potentiator of multiple cancer-promoting genes and required for liver and colon cancer development
Sarris ME, et al.
Cancer Cell, 29(3), 354-366 (2016)
Occurrence and control of N-nitrosodimethylamine in water engineering systems
Bian Y, et al.
Environmental Engineering Research, 24(1), 1-16 (2018)
Diane Fournier et al.
Applied and environmental microbiology, 72(10), 6693-6698 (2006-09-05)
N-Nitrosodimethylamine (NDMA) is a potent carcinogen and an emerging contaminant in groundwater and drinking water. The metabolism of NDMA in mammalian cells has been widely studied, but little information is available concerning the microbial transformation of this compound. The objective

文章

DNA 損傷和修復機制對維持 DNA 的完整性至關重要。細胞 DNA 的損害與突變、癌症的發展等有關。

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

Questions

  1. What is the concentration of product N0756?

    1 answer
    1. The concentration of product N0756 is 9.3 M, calculated using a density of 0.95 g/mL and a molecular weight of 102.14 g/mole.

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