N2286

无活菌素

from Streptomyces griseus, ≥98.0% (Total homologs, HPLC)

• 同義詞: 铵离子载体
• 經驗公式（希爾表示法）: C₄₀H₆₄O₁₂
• CAS號碼: 6833-84-7
• 分子量：: 736.93
• Beilstein: 76434
• EC號碼: 229-911-3
• 分類程式碼代碼: 51102829
• PubChem物質ID: 24897566
• NACRES: NA.76

屬性

• 生物源: Streptomyces griseus
• 品質等級: 300
• 描述: Natural macrotetrolide, may contain homologues (like monactin and dinactin)
• 化驗: ≥98.0% (Total homologs, HPLC)
• 形狀: powder
• 溶解度: chloroform: soluble 10 mg/mL
• 抗生素活性譜: Gram-positive bacteria
• 作用方式: DNA synthesis | interferes; cell membrane | interferes
• 儲存溫度: 2-8°C
• SMILES 字串: C[C@H]1C[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O[C@H](C)C[C@H]3CC[C@H](O3)[C@H](C)C(=O)O[C@@H](C)C[C@@H]4CC[C@@H](O4)[C@@H](C)C(=O)O[C@H](C)C[C@H]5CC[C@H](O5)[C@H](C)C(=O)O1
• InChI: 1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-
• InChI 密鑰: RMIXHJPMNBXMBU-QIIXEHPYSA-N

描述

一般說明

Chemical structure: macrolide

應用

Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is an uncoupler of oxidative phosphorylation [1].

生化／生理作用

Nonactin is used as a neutral lipid membrane soluble ammonium (and potassium) ionophore, and to inhibit surface expression of certain heat shock proteins (HSP60) [2][3].

其他說明

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)