N158
Naftopidil hydrochloride hydrate
solid
同義詞:
4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride hydrate, KT-611
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About This Item
經驗公式（希爾表示法）:
C24H28N2O3 · xHCl · yH2O
CAS號碼:
分子量：:
392.49 (anhydrous free base basis)
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
形狀
solid
顏色
white
溶解度
methanol: >10 mg/mL
H2O: insoluble
SMILES 字串
O.Cl.COc1ccccc1N2CCN(CC2)CC(O)COc3cccc4ccccc34
InChI
1S/C24H28N2O3.ClH.H2O/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23;;/h2-12,20,27H,13-18H2,1H3;1H;1H2
InChI 密鑰
INIDYCYXDNFBSV-UHFFFAOYSA-N
基因資訊
human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)
生化／生理作用
α1-Adrenoceptor antagonist; antihypertensive.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Akinobu Gotoh et al.
Pharmacology, 90(5-6), 242-246 (2012-09-26)
The present study investigated the antitumor action of α(1)-adrenoceptor blockers on human bladder, prostate and renal cancer cells. For bladder cancer cell lines used here such as 253J, 5637, KK-47, T24 and UM-UC-3 cells, prazosin, a selective α(1)-adrenoceptor blocker, reduced
Mitsunobu Masuda et al.
Hinyokika kiyo. Acta urologica Japonica, 58(12), 671-678 (2013-01-19)
We compared the efficacy, safety, and patient preferences for two α1-adrenoceptor (AR) antagonists with different affinity for AR subtypes, naftopidil (Naf) and silodosin (Silo), for the treatment of male lower urinary tract symptoms associated with benign prostatic hyperplasia (male LUTS/BPH).
Shui Gen Zhou et al.
World journal of urology, 29(6), 767-771 (2011-08-17)
To compare the efficacy of α(1)D-receptor antagonist Naftopidil and α(1)A/D-receptor antagonist Tamsulosin in management of distal ureteral stones. A total of 131 patients with distal ureteral stones were included in the study from December 2008 to September 2010. The patients
Satoshi Tatemichi et al.
Urology, 80(2), 486-486 (2012-06-09)
To compare the effects of four α(1)-adrenoceptor (AR) subtype-selective antagonists on ejaculatory function in rats to investigate whether the differences in their modes of action-based on their selectivities for the α(1A)-AR subtype-would be related to the prevalence of ejaculation disorder
Tomokazu Sazuka et al.
Journal of endourology, 26(9), 1216-1220 (2012-04-11)
To examine the efficacy of an alpha-1 blocker and its correlation to structural alteration of the prostatic urethra and the loss of energy in the urine flow using a virtual urethra processed from an endoscopic video image. Video images of
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