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Merck
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重要文件

M1574

Sigma-Aldrich

Miglitol

同義詞:

1-(2-Hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol

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About This Item

經驗公式(希爾表示法):
C8H17NO5
CAS號碼:
分子量::
207.22
EC號碼:
分類程式碼代碼:
12352205
NACRES:
NA.25
暫時無法取得訂價和供貨情況

生物源

synthetic (organic)

品質等級

化驗

≥98% (HPLC)

形狀

powder

mp

142-147  °C

溶解度

water: 5 mg/mL, clear, colorless to faintly yellow

儲存溫度

room temp

SMILES 字串

N1([C@@H]([C@H]([C@@H]([C@H](C1)O)O)O)CO)CCO

InChI

1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1

InChI 密鑰

IBAQFPQHRJAVAV-ULAWRXDQSA-N

一般說明

Miglitol is an alpha-glucosidase inhibitor used as a glucose-lowering drug in diabetes research.[1]

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Kazuki Mochizuki et al.
Metabolism: clinical and experimental, 60(11), 1560-1565 (2011-05-10)
Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes mellitus, exhibit chronic and slowly progressive hyperglycemia with obesity. In this study, we examined whether dietary supplementation with the α-glucosidase inhibitor miglitol from the preonset stage improves
Kazuki Mochizuki et al.
Bioscience, biotechnology, and biochemistry, 74(12), 2470-2474 (2010-12-15)
β(2) integrins (CD11s/CD18) promote the attachment of leukocytes to vascular endothelial cells. We performed in this study sucrose loading to rats with moderate postprandial hyperglycemia with/without once-daily dosing of the α-glucosidase inhibitor, miglitol, for 4 days under 4-h fasting conditions.
Kyra Jones et al.
Bioorganic & medicinal chemistry, 19(13), 3929-3934 (2011-06-15)
Inhibition of intestinal α-glucosidases and pancreatic α-amylases is an approach to controlling blood glucose and serum insulin levels in individuals with Type II diabetes. The two human intestinal glucosidases are maltase-glucoamylase and sucrase-isomaltase. Each incorporates two family 31 glycoside hydrolases
Kazutaka Aoki et al.
Acta diabetologica, 49(3), 225-230 (2011-09-08)
We recently reported that the administration of miglitol alone just before breakfast improved postprandial hyperglycemia and increased active glucagon-like peptide-1 (GLP-1) levels after lunch in men without diabetes. Miglitol and dipeptidyl peptidase-4 inhibitors, such as sitagliptin, enhance plasma active GLP-1
Kenichi Matsuura et al.
Diabetes technology & therapeutics, 14(5), 423-429 (2012-02-10)
We compared the effects of miglitol as an add-on to bolus insulin and dose-intensified bolus insulin on postprandial glycemic excursions by continuous glucose monitoring (CGM). The glucose levels of 21 type 2 diabetes patients admitted for glycemic control were monitored

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