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Merck
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文件

G110

Sigma-Aldrich

胍那苄 乙酸盐

powder

同義詞:

1-(2,6-二氯亚苄基氨基)胍 乙酸盐, WY-8678

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About This Item

經驗公式（希爾表示法）:
C8H8Cl2N4 · C2H4O2
CAS號碼:
23256-50-0
分子量：:
291.13
EC號碼:
245-534-7
MDL號碼:
MFCD00153801
分類程式碼代碼:
12352200
PubChem物質ID:
24277775
NACRES:
NA.77

形狀

powder

顏色

white

溶解度

H2O: 10 mg/mL
alcohol: 50 mg/mL

起源

Wyeth

SMILES 字串

CC(O)=O.NC(=N)N\N=C\c1c(Cl)cccc1Cl

InChI

1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;

InChI 密鑰

MCSPBPXATWBACD-GAYQJXMFSA-N

基因資訊

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

尋找類似的產品？ 前往 產品比較指南

生化／生理作用

中枢作用的α2 肾上腺素能受体激动剂；I2 咪唑啉结合位点配体；抗高血压活性。

特點和優勢

《受体分类和信号转导》手册的 α2-肾上腺素受体 以及 咪唑啉结合位点 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物由 Wyeth 开发 。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表， 点击这里 。
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301

防範說明

P301 + P310

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

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Déborah Tribouillard-Tanvier et al.
PloS one, 3(4), e1981-e1981 (2008-04-24)
Prion-based diseases are incurable transmissible neurodegenerative disorders affecting animals and humans. Here we report the discovery of the in vivo antiprion activity of Guanabenz (GA), an agonist of alpha2-adrenergic receptors routinely used in human medicine as an antihypertensive drug. We
B Holmes et al.
Drugs, 26(3), 212-229 (1983-09-01)
Guanabenz is an orally active central alpha 2-adrenoceptor agonist. Its antihypertensive action is thought to result from a decrease in sympathetic outflow from the brain to the peripheral circulatory system as a result of stimulation of central alpha 2-adrenoceptors. In
Melissa J Fullwood et al.
Progress in molecular biology and translational science, 106, 75-106 (2012-02-22)
The unfolded protein response, also known as endoplasmic reticulum (ER) stress, has been implicated in numerous human diseases, including atherosclerosis, cancer, diabetes, and neurodegenerative disorders. Protein misfolding activates one or more of the three ER transmembrane sensors to initiate a
Suzana Dos Reis et al.
Biochimie, 93(6), 1047-1054 (2011-03-15)
The ribosome, the protein synthesis machinery of the cell, has also been implicated in protein folding. This activity resides within the domain V of the main RNA component of the large subunit of the ribosome. It has been shown that
Pavel Tsaytler et al.
The FEBS journal, 280(2), 766-770 (2012-02-22)
Selective and reversible phosphorylation is one of the most common post-translational modifications of proteins. Although kinase inhibitors are popular in drug development programmes, selective pharmacological manipulation of phosphatase activity has been challenging to achieve. We review recent advances in the
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