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Merck
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重要文件

L6292

Sigma-Aldrich

赖诺普利

≥98% (HPLC)

同義詞:

MK-521, (S)-1- [N2-(1-羧基-3-苯丙基)-赖氨酰脯氨酸 二水合物

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About This Item

經驗公式(希爾表示法):
C21H31O5N3 · 2H2O
CAS號碼:
分子量::
441.52
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.32
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化驗

≥98% (HPLC)

形狀

solid

顏色

white

溶解度

H2O: ≥10 mg/mL
DMSO: ~6.5 mg/mL (with heating and sonicating)

儲存溫度

2-8°C

SMILES 字串

[H]O[H].[H]O[H].NCCCC[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N2CCC[C@H]2C(O)=O

InChI

1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1

InChI 密鑰

CZRQXSDBMCMPNJ-ZUIPZQNBSA-N

基因資訊

human ... ACE(1636)

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應用

赖诺普利已被用于研究杜氏营养不良症小鼠的抗纤维化作用。[1]它已被用于研究经过长期达贝泊汀处理后的 TGR(mRen2)27 (携带小鼠 Ren-2 基因的转基因大鼠)大鼠的肾结构和功能的变化。[2]

生化/生理作用

血管紧张素转换酶(ACE)抑制剂。

特點和優勢

该化合物是位于美国新泽西Kenilworth的Merck & Co., Inc.开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单, 请单击此处

象形圖

Health hazard

訊號詞

Danger

危險聲明

危險分類

Repr. 1A - STOT RE 2

標靶器官

Kidney

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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