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M006

Sigma-Aldrich

丙谷胺 钠盐

solid

同義詞:

4-苯甲酰氨基-5-二丙氨基-5-氧代戊酸 钠-钾盐, N-苯甲酰基-N′,N′-二丙基-DL-异谷氨酰胺 钠-钾盐

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About This Item

經驗公式（希爾表示法）:
C18H25N2NaO4
CAS號碼:
99247-33-3
分子量：:
356.39
MDL號碼:
MFCD00069301
分類程式碼代碼:
12352200
PubChem物質ID:
24896533
NACRES:
NA.77
暫時無法取得訂價和供貨情況

形狀

solid

顏色

white

溶解度

H2O: soluble

SMILES 字串

[Na+].CCCN(CCC)C(=O)C(CCC([O-])=O)NC(=O)c1ccccc1

InChI

1S/C18H26N2O4.Na/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14;/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22);/q;+1/p-1

InChI 密鑰

UFMWGCINVOIJSO-UHFFFAOYSA-M

基因資訊

human ... CCK(885) , CCKAR(886) , CCKBR(887)
mouse ... CCK(12424)
rat ... CCK(25298)

應用

丙谷胺钠盐已被用于研究丙谷胺对欧洲鲈鱼，舌齿鲈中宏营养物质选择的影响。[1]

生化／生理作用

CCK拮抗剂；选择性地阻断CNS效应。
丙谷胺钠盐是一种非肽胆囊收缩素受体拮抗剂[2]，其对CCKA亚型具有更高的选择性。它可有选择地阻止中枢神经系统的影响。丙谷胺钠盐具有口服活性。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析證明 (COA)

Lot/Batch Number
0000027600
0000022775
066M4611V
115M4609V
095M4609V

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The cholecystokinin antagonist, proglumide, increases food intake in the rat
G.Shillabeer and J. Davidson
Regulatory Peptides (1984)
E S Corp et al.
Physiology & behavior, 61(6), 823-827 (1997-06-01)
Cholecystokinin (CCK) receptors are classified as two subtypes, designated CCK(A) and CCK(B), and both subtypes are found in brain and peripheral tissues of rats. CCK-8 has been shown to act peripherally to reduce meal size, and this satiating action can
Role of cholecystokinin and its antagonist proglumide on macronutrient selection in European sea bass Dicentrarchus labrax, L.
V. C. Rubio
Physiology & Behavior (2008)
J V Menani et al.
The American journal of physiology, 275(5 Pt 2), R1431-R1437 (1998-10-29)
The present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II
James M Hill et al.
Science translational medicine, 6(265), 265ra169-265ra169 (2014-12-05)
Herpesviruses are highly prevalent and maintain lifelong latent reservoirs, thus posing challenges to the control of herpetic disease despite the availability of antiviral pharmaceuticals that target viral DNA replication. The initiation of herpes simplex virus infection and reactivation from latency
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