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Merck
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重要文件

M003

Sigma-Aldrich

R-(−)-异戊烯基 盐酸盐

powder, ≥98% (HPLC)

同義詞:

(R)-(−)-N,α-Dimethyl-N-(2-propynyl)phenethylamine hydrochloride, R(−)-N-α-Dimethyl-N-2-propynyl-benzeneethanamine hydrochloride, Selegiline hydrochloride

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About This Item

經驗公式(希爾表示法):
C13H17N · HCl
CAS號碼:
分子量::
223.74
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]25/D −10.8°, c = 6.48 in H2O(lit.)

顏色

white

mp

141-142  °C

溶解度

H2O: >10 mg/mL

起源

Sanofi Aventis

SMILES 字串

Cl[H].C[C@H](Cc1ccccc1)N(C)CC#C

InChI

1S/C13H17N.ClH/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13;/h1,5-9,12H,10-11H2,2-3H3;1H/t12-;/m1./s1

InChI 密鑰

IYETZZCWLLUHIJ-UTONKHPSSA-N

基因資訊

human ... MAOB(4129)

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生化/生理作用

Selective MAO-B inhibitor; anti-Parkinsonian agent.

特點和優勢

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

防範說明

危險分類

Acute Tox. 4 Oral - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Dominic Lomiwes et al.
Journal of agricultural and food chemistry, 72(30), 16777-16789 (2024-07-19)
Previous clinical studies indicate that monoamine oxidase-B (MAO-B) inhibition by blackcurrants must be predominantly attributed to bioactives other than anthocyanins. In this natural products discovery study, MAO-A/B inhibitory phytochemicals were isolated from blackcurrants, and a double-blind crossover study investigated the
Michael M Monaghan et al.
Neuro-degenerative diseases, 7(1-3), 153-159 (2010-03-04)
Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by an increasing loss of dopaminergic neurons resulting in motor dysfunction. However, cognitive impairments in PD patients are a common clinical feature that has gained increased attention. The purpose of the
Olivia J Kalimon et al.
Experimental neurology, 363, 114356-114356 (2023-02-26)
Monoamine oxidase (MAO) is an enzyme located on the outer mitochondrial membrane that metabolizes amine substrates like serotonin, norepinephrine and dopamine. MAO inhibitors (MAOIs) are frequently utilized to treat disorders such as major depression or Parkinson's disease (PD), though their
Hojae Lee et al.
Nature neuroscience, 24(12), 1673-1685 (2021-11-17)
Amyotrophic lateral sclerosis (ALS) is a devastating disorder in which motor neurons degenerate, the causes of which remain unclear. In particular, the basis for selective vulnerability of spinal motor neurons (sMNs) and resistance of ocular motor neurons to degeneration in
Edward E Putnins et al.
Frontiers in pharmacology, 12, 741460-741460 (2021-12-07)
Mucosal epithelial cell integrity is an important component of innate immunity and it protects the host from an environment rich in microorganisms. Virulence factors from Gram-negative bacteria [e.g. lipopolysaccharide (LPS)] induce significant pro-inflammatory cytokine expression. Monoamine oxidase (MAO) inhibitors reduce

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