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推薦產品
生物源
bovine milk
品質等級
形狀
powder
分子量
~14.2 kDa
包裝
vial of 5 mg
濃度
>5 mg per vial protein (biuret)
技術
electrophoresis: suitable
溶解度
H2O: soluble 10 mg/mL
UniProt登錄號
儲存溫度
2-8°C
基因資訊
cow ... LALBA(281894)
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一般說明
α-乳清蛋白是一种分子量较小的球状乳清蛋白,存在于迄今为止已研究的所有乳汁中。它是在乳腺中产生的大约 14 kDa 的金属蛋白。[1]
應用
生化/生理作用
α-乳清蛋白由具有 8 个半胱氨酸的单条多肽链组成,这些半胱氨酸形成二硫键。α-乳清蛋白结合包括钙在内的几种金属离子,人们认为该结合在从还原的变性形式的 α-乳清蛋白再生成天然 α-乳清蛋白的过程中发挥作用。[7]α-乳清蛋白还具有独特的锌结合位点,其被认为在乳糖合酶复合物的结合中起作用。[8][9] 其成熟蛋白由 123 个氨基酸残基(14kD)组成,具有 1.7 埃分辨率的三维结构,包含四个 α-螺旋和三链反平行 β-折叠。[1]
其可通过改变半乳糖基转移酶的底物特异性以增加乳糖形成的速率;半乳糖基转移酶和 α-乳白蛋白的复合物称为乳糖合酶。
其可通过改变半乳糖基转移酶的底物特异性以增加乳糖形成的速率;半乳糖基转移酶和α-乳白蛋白的复合物称为乳糖合酶。Asp87 或 Asp88 对 Ala 的定点诱变完全消除了强钙结合亲和力,并将乳糖合酶的刺激降低到最大速率的 <3.5%。
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分析證明 (COA)
Lot/Batch Number
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