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K1750

Sigma-Aldrich

α-酮戊二酸

≥98.5% (NaOH, titration)

同義詞:

2-氧代戊二酸, 2-氧化戊二酸

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About This Item

線性公式:
HOOCCH2CH2COCOOH
CAS號碼:
328-50-7
分子量：:
146.10
Beilstein:
1705689
EC號碼:
206-330-3
MDL號碼:
MFCD00004165
分類程式碼代碼:
12352204
PubChem物質ID:
57654314
NACRES:
NA.32

品質等級

200

化驗

≥98.5% (NaOH, titration)

形狀

powder

溶解度

water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

儲存溫度

2-8°C

SMILES 字串

OC(=O)CCC(=O)C(O)=O

InChI

1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)

InChI 密鑰

KPGXRSRHYNQIFN-UHFFFAOYSA-N

尋找類似的產品？ 前往 產品比較指南

一般說明

αα-酮戊二酸(α-KG)在三羧酸循环中产生。

應用

αα-酮戊二酸(α-KG)已用于：
  • 研究其在体外发酵系统中对猪粪菌群的影响
  • 研究其对CD8+ T细胞的影响
  • 在谷氨酸-草酰乙酸转氨酶(GOT)线粒体裂解物检测中作为底物

生化／生理作用

αα-酮戊二酸(α-KG)广泛应用于动物饲料、食品、制药和精细化工行业。

象形圖

Corrosion
GHS05

訊號詞

Danger

危險聲明

H318

危險分類

Eye Dam. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

分析證明 (COA)

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Long Liu et al.
Journal of biotechnology, 164(1), 97-104 (2013-01-22)
Currently, α-ketoglutaric acid (α-KG) is industrially produced by multi-step chemical synthesis, which can cause heavy environmental pollution. Here we reported a simple one-step approach for the production of α-KG by transforming l-glutamic acid with an engineered l-amino acid deaminase (l-AAD)
G Biagi et al.
Journal of animal science, 85(5), 1184-1191 (2007-02-14)
Adding organic acids to piglet diets is known to be helpful in overcoming postweaning syndrome, and butyric acid is known to be the main energy source for the epithelial cells of the large intestine and the terminal ileum. This study
J Kitaura et al.
European journal of pediatrics, 158(5), 410-413 (1999-05-20)
Two cases of hyperinsulinaemic hypoglycaemia associated with persistent hyperammonaemia in unrelated infants of 7 days and 4 months of age are reported. Blood ammonia levels were 100-300 micromol/l (normal values <40 micromol/l). The hyperammonaemia was asymptomatic and not associated with
F Rocchiccioli et al.
Biomedical mass spectrometry, 11(1), 24-28 (1984-01-01)
Quantification of 2-ketoglutaric acid in plasma and cerebrospinal fluid as its O-trimethylsilyl++-quinoxalinol derivative by gas chromatography chemical ionization mass spectrometry is described with benzoylformic acid as internal standard. This technique, with ammonia as reactant gas, only detects the protonated molecular
Victoria I Bunik et al.
International journal of molecular sciences, 21(11) (2020-05-30)
Genetic up-regulation of mitochondrial 2-oxoglutarate dehydrogenase is known to increase reactive oxygen species, being detrimental for cancer cells. Thiamine diphosphate (ThDP, cocarboxylase) is an essential activator of the enzyme and inhibits p53-DNA binding in cancer cells. We hypothesize that the
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