推薦產品
產品線
BioReagent
化驗
≥98.5% NaOH basis (titration)
形狀
powder or crystals
技術
cell culture | insect: suitable
cell culture | mammalian: suitable
溶解度
water: 100 mg/mL, clear to slightly hazy, colorless to almost colorless
儲存溫度
2-8°C
SMILES 字串
OC(=O)CCC(=O)C(O)=O
InChI
1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChI 密鑰
KPGXRSRHYNQIFN-UHFFFAOYSA-N
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一般說明
α-酮戊二酸(αKG)是三羧酸 (TCA)/Krebs循环中的琥珀酰辅酶 A 和异柠檬酸之间重要的中间产物。
應用
α--酮戊二酸已用于：
- 作为最低基础培养基α (α-MEM)的补充剂，培养原代间充质基质细胞/干细胞 (MSC)， 以研究其对年龄相关性骨质疏松症的影响
- 化学治疗，以在手动和自动寿命机器 (ALM) 平台之间，比较几种化合物对寿命的治疗效果
- 用作打印趋化因子配体，使用高通量技术筛选趋化因子受体并验证与表面等离子体共振 (SPR) 的相互作用
生化／生理作用
α-酮戊二酸(αKG)是一种氮清除剂，是谷氨酸和谷氨酰胺的重要来源。它负责控制ATP合成并减少三羧酸 (TCA) 循环中的等价物 (NAD+/NADH) 生成。它可促进蛋白质合成，防止肌肉中的蛋白质降解。这种免疫营养因子参与一般免疫和胶原蛋白代谢。在老年啮齿动物中，αKG可加速骨缺损愈合，可能具有潜在抗衰老作用。这种Krebs循环分子可用作昆虫和哺乳动物细胞培养的补充剂。
訊號詞
Danger
危險聲明
危險分類
Eye Dam. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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