跳轉至內容
Merck
全部照片(1)

重要文件

J4455

Sigma-Aldrich

JSH-23

≥98% (HPLC), solid

同義詞:

4-甲基-N1-(3-苯基丙基)-1,2-苯二胺

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C16H20N2
CAS號碼:
分子量::
240.34
分類程式碼代碼:
51111800
NACRES:
NA.77
暫時無法取得訂價和供貨情況

品質等級

化驗

≥98% (HPLC)

形狀

solid

儲存條件

protect from light

顏色

off-white to gray-pink

溶解度

DMSO: >10 mg/mL

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

N(CCCc2ccccc2)c1c(cc(cc1)C)N

InChI

1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3

InChI 密鑰

YMFNPBSZFWXMAD-UHFFFAOYSA-N

應用

JSH-23 已被用作一种核因子 κB(NF-κB)p65 抑制剂。[1][2][3]

生化/生理作用

JSH-23 是一种 NF-κB 核易位抑制剂。
JSH-23 是一种 NF-κB 核易位抑制剂。EMSA 和蛋白质印迹分析表明,它抑制 LPS 和细胞因子诱导的 NF-kB p65 亚基的核易位过程。该化合物具有适度的抑制活性(RAW 264.7 细胞中 IC50 值为 7.1 uM),但不影响 IkB 降解或恢复。该化合物以剂量依赖性方式抑制 LPS 诱导的细胞因子、COX2 和 iNOS 的表达,并且可能结合或干扰 p65 的和定位信号(NLS)。

其他說明

光和空气敏感。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

未看到正確版本?

如果您需要一個特定的版本,您可以透過批號來尋找特定憑證。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

L Shi et al.
Oncogene, 36(12), 1631-1643 (2016-11-22)
The coordination between cellular differentiation and the mesenchymal/stem transition is essential for both embryo development and neoplasia, suggesting a mechanistic link between these two major processes. In this work we show that miR-127, an embryo-expressing lung miRNA, was prominently induced
HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-?B pathway in acute glaucoma.
Chi W et al.
Journal of Neuroinflammation, 12, 137-137 (2015)
Macrophage TCF-4 co-activates p65 to potentiate chronic inflammation and insulin resistance in mice.
Kang X et al.
Clinical Science (London, England : 1979), 130, 1257-1257 (2016)
Xia Kang et al.
Clinical science (London, England : 1979), 130(14), 1257-1268 (2016-04-30)
Transcription factor 4 (TCF-4) was recently identified as a candidate gene for the cause of type 2 diabetes, although the mechanisms have not been fully elucidated. In the present study, we demonstrated that the TCF-4 transgene in macrophages aggravated high-fat diet
Meibao Feng et al.
Molecular cancer, 15(1), 77-77 (2016-12-04)
Lipocalin2 (LCN2) is a secretory protein that is aberrantly expressed in several types of cancer and has been involved in metastatic progression. However, neither mechanisms nor the role that LCN2 plays in the metastasis of colorectal cancer are clear. LCN2

Questions

Reviews

No rating value

Active Filters

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務