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Key Documents

H9762

Sigma-Aldrich

Haptoglobin Human, Phenotype 2-2

98-100%, essentially salt-free, lyophilized powder

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.61

生物源

human

品質等級

化驗

98-100%

形狀

essentially salt-free, lyophilized powder

容量

>0.5 mg/mg (hemoglobin)

溶解度

H2O: soluble 10 mg/mL

UniProt登錄號

儲存溫度

2-8°C

基因資訊

human ... HP(3240)

一般說明

Haptoglobin is an α2-globulin found in normal plasma at a concentration of 82-236 mg/dl and accounts for 0.4-2.6% of the total plasma proteins. . The monomeric form of this acute phase plasma protein is composed of four polypeptide chains: two α chains and two β chains.
Haptoglobin is an acute phase protein that scavenges hemoglobin released into the circulation. Haptoglobin, the plasma protein with highest binding affinity to hemoglobin, is mainly expressed in the liver.

應用

Haptoglobin was used to study haptoglobin expression and release by rabbit oviduct and endometrium. It was also used to analyze its localization in blastocyst extra-embryonic matrix and fluid during pre-implantation.

其他說明

Occurs as 3 major phenotypes: type 1-1, type 2-1, type 2-2.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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A Herrler et al.
Human reproduction (Oxford, England), 19(12), 2730-2737 (2004-09-25)
Evidence is emerging that haptoglobin, an acute phase protein with immunomodulatory properties, is expressed by the endometrium of various species. The present study describes an in-depth investigation of haptoglobin expression and release in the rabbit reproductive tract and in preimplantation
Hanne Van Gorp et al.
The Journal of general virology, 89(Pt 12), 2943-2953 (2008-11-15)
The porcine reproductive and respiratory syndrome virus (PRRSV) shows a restricted tropism for subsets of porcine macrophages in vivo. To date, two PRRSV receptors have been identified on primary macrophages, heparan sulphate for binding and sialoadhesin for binding and internalization.
C Gerbert et al.
Journal of dairy science, 101(8), 7348-7360 (2018-05-21)
Animal welfare in dairy calf husbandry depends on calf rearing and is probably improved by intensive milk feeding programs. In addition, butyrate supplementation in milk replacer (MR) stimulates postnatal growth and may affect the immune system in calves. We have
Laust Dupont et al.
Progress in transplantation (Aliso Viejo, Calif.), 27(4), 386-391 (2017-12-01)
Cardiovascular disease is the leading cause of death in renal transplant recipients. An association between haptoglobin genotype 2-2 and cardiovascular disease has been found in patients with diabetes mellitus and liver transplant recipients. To date, the role of haptoglobin genotype
I B Ross et al.
Journal of neurotrauma, 8(4), 229-238 (1991-01-01)
Previously in our laboratory, nimodipine was effective in reversing posttraumatic ischemia and promoting electrophysiologic recovery in a rat spinal cord injury (SCI) model. However, these beneficial effects were achieved when nimodipine was combined with adjuvant therapy to reverse posttraumatic hypotension

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