推薦產品
生物源
Staphylococcus aureus
品質等級
形狀
lyophilized powder
比活性
≥10,000 units/mg protein
包含
sodium citrate buffer as balance
成份
Protein, ~60% Lowry
溶解度
H2O: soluble 0.49-0.51 mg/mL
UniProt登錄號
儲存溫度
2-8°C
基因資訊
Staphylococcus aureus ... SAOUHSC_01121(3920722)
一般說明
α-溶血素是一种成孔细胞毒素，它是大多数致病性金黄色葡萄球菌菌株分泌的一种细胞外蛋白。它是以水溶性单体的形式分泌，是一种小型β桶状蛋白。
應用
α-来自金黄色葡萄球菌的溶血素已被用于:
- 作为电解质溶液的一种成分，用于通过电生理测量测试脂双层中的孔形成
- 测试其在骨髓基质细胞（BMSCs）中的成骨抑制作用
- 制备用于 Biacore 和表面等离子体共振的α溶血素分子印迹聚合物 (MIP)
α-溶血素被用于一项研究，用于测试乳制品大肠杆菌的外排泵和溶血素活性。它还用于测试其对苯扎氯铵的适应性以及环丙沙星对生物膜形成的影响。
生化／生理作用
α-溶血素是选择性溶血的，单体形式与膜结合，结合不需要特异性受体。在与生物膜和/或人造膜结合后，它会发生自身低聚化，从而产生代表跨膜孔的环状结构（六聚体），这些孔对离子和小代谢物是通透的。它对兔红细胞有明显的偏好。α-溶血素刺激细胞磷脂酶并诱导 Ca2+流入。它导致内皮屏障的膜破坏和细胞质成分的泄漏和细胞的渗透裂解。α-溶血素与脓毒症的发病机制有关。
包裝
包装尺寸基于蛋白质含量
單位定義
一个溶血单元是在 37°C 下 30 分钟，然后在 4°C 下冷藏 30 分钟后，悬浮在 pH 7.0 磷酸盐缓冲盐水中含1% 牛血清白蛋白的 1% 兔红细胞有50%溶解。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 2
標靶器官
Lungs,Blood
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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相關內容
細胞裂解與蛋白質萃取方法概述各種技術，從洗滌劑溶解到機械破壞，支援研究需求。
Cell lysis and protein extraction methods overview various techniques, from detergent solubilization to mechanical disruption, supporting research needs.
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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