跳轉至內容
Merck
全部照片(1)

重要文件

E8640

Sigma-Aldrich

E-64d

powder, ≥98% (TLC)

同義詞:

(2S,3S)-反式-环氧琥珀酰基-L-亮氨酰氨基-3-甲基丁烷乙酯, EST

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C17H30N2O5
CAS號碼:
分子量::
342.43
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

產品名稱

E-64d, protease inhibitor

生物源

synthetic (organic)

品質等級

化驗

≥98% (TLC)

形狀

powder

溶解度

methanol: water (1:1): 5 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C

InChI

1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1

InChI 密鑰

SRVFFFJZQVENJC-IHRRRGAJSA-N

基因資訊

human ... CAPN1(823)

應用

E-64d已作为一种溶酶体抑制剂,被用于人类急性早幼粒细胞白血病NB4细胞[1] 和Huh-7细胞中。[2]它也已作为一种蛋白酶抑制剂,被用于游离钙生理酪氨酸溶液中,以用于对分离出的心脏样本的灌注。[3]

生化/生理作用

E-64d是一种环氧琥珀酰肽,以及半胱氨酸蛋白酶组织蛋白酶B、[4]钙蛋白酶1和2的抑制剂。[5] E-64d具有对组织蛋白酶B蛋白酶的抑制功能,可作为治疗颅脑外伤(TBI)[5]和阿尔茨海默氏症′(AD)的潜在药物。[6]它可抑制配子体表面抗原,从而减少恶性疟原虫卵囊的产生。[7]

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

未看到正確版本?

如果您需要一個特定的版本,您可以透過批號來尋找特定憑證。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation
Yamada D, et al.
Biochemical and Biophysical Research Communications, 471(1), 109-116 (2016)
John P Lloyd et al.
Scientific reports, 9(1), 12122-12122 (2019-08-23)
Extensive transcriptional activity occurring in intergenic regions of genomes has raised the question whether intergenic transcription represents the activity of novel genes or noisy expression. To address this, we evaluated cross-species and post-duplication sequence and expression conservation of intergenic transcribed
Weidong Huang et al.
Scientific reports, 7(1), 13354-13354 (2017-10-19)
A cDNA library from a pool of all the seven silk glands from a tropical spider species was constructed. More than 1000 expressed sequence tag (EST) clones were created. Almost 65% of the EST clones were identified and around 50%
E64d, a membrane-permeable cysteine protease inhibitor, attenuates the effects of parathyroid hormone on osteoblasts in vitro
Murray EJ, et al.
Metabolism and Disease, 46(9), 1090-1094 (1997)
Inhibition of Plasmodium falciparum oocyst production by membrane-permeant cysteine protease inhibitor E64d
Eksi S, et al.
Antimicrobial Agents and Chemotherapy, 51(3), 1064-1070 (2007)

Questions

1–5 of 5 Questions  
  1. What can I dissolve Product E8640, E-64d, in?

    1 answer
    1. According to McGowan, E. B. et al., Biochem. Biophys. Res. Comm., 158(2), 432-435 (1989), this compound was dissolved in DMSO up to 200 mg/mL for use as an inhibitor of calpain in both intact and lysed platelets..

      Helpful?

  2. Where can solutions of Product E8640, E-64d, be stored?

    1 answer
    1. According to McGowan, E. B. et al., Biochem. Biophys. Res. Comm., 158(2), 432-435 (1989), solutions made in DMSO were stored at -70°C.

      Helpful?

  3. What is the difference between E-64, E-64c and E-64d?

    1 answer
    1. E-64c is a synthetic analog of E-64.  E-64d is the ethyl ester of E-64c.  E-64c is not cell permeable, but E-64d is cell permeable.  E-64d is hydrolyzed in cell culture to E-64c.

      Helpful?

  4. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  5. How does the storage temperature relate to shipping conditions?

    1 answer
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Helpful?

Reviews

No rating value

Active Filters

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務