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Merck
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重要文件

E4132

Sigma-Aldrich

1,N6-Etheno-2′-deoxyadenosine

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About This Item

經驗公式(希爾表示法):
C12H13N5O3
CAS號碼:
分子量::
275.26
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:

形狀

solid

儲存溫度

−20°C

SMILES 字串

OCC1OC(CC1O)n2cnc3c2ncn4ccnc34

InChI

1S/C12H13N5O3/c18-4-8-7(19)3-9(20-8)17-6-14-10-11-13-1-2-16(11)5-15-12(10)17/h1-2,5-9,18-19H,3-4H2

InChI 密鑰

XQQIMTUYVDUWKJ-UHFFFAOYSA-N

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Poh-Gek Forkert et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(5), 713-720 (2007-02-14)
Vinyl carbamate (VC) is derived from ethyl carbamate, a carcinogen formed in fermentation of food and alcoholic products. We have undertaken studies to test the hypothesis that an epoxide generated from VC oxidation leads to formation of 1,N6-ethenodeoxyadenosine (epsilon dAS).
Qingming Fang et al.
Mutation research, 624(1-2), 71-79 (2007-05-25)
Intake of linoleic acid (LA) increased etheno-DNA adducts induced by lipid peroxidation (LPO) in white blood cells (WBC) of female but not of male volunteers [J. Nair, C.E. Vaca, I. Velic, M. Mutanen, L.M. Valsta, H. Bartsch, High dietary omega-6
Andreas Brink et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 830(2), 255-261 (2005-11-22)
O(6)-Methyl-2'-deoxyguanosine (O(6)-mdGuo), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo), and 1,N(6)-etheno-2'-deoxyadenosine (epsilondAdo) are promutagenic DNA lesions originating from both endogenous and exogenous agents and actions (methylation, hydroxylation, lipid peroxidation products). A highly sensitive quantitative method was developed to measure these DNA adducts simultaneously, using liquid
Deepak T Nair et al.
Nature structural & molecular biology, 13(7), 619-625 (2006-07-05)
The 1,N6-ethenodeoxyadenosine (epsilon dA) lesion is promutagenic and has been implicated in carcinogenesis. We show here that human Pol iota, a Y-family DNA polymerase, can promote replication through this lesion by proficiently incorporating a nucleotide opposite it. The structural basis
Somkid Dechakhamphu et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17(7), 1658-1664 (2008-07-17)
Chronic infection by Opisthorchis viverrini (OV) is a strong risk factor for developing cholangiocarcinoma (CCA). To clarify the involvement of oxidative stress and lipid peroxidation (LPO)-derived DNA damage, the excretion of LPO-derived etheno DNA adducts was measured in urine samples

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