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重要文件

303410

Sigma-Aldrich

丁酸钠

Sodium butyrate
1 of 2 reviewers received a sample product or took part in a promotion

98%

同義詞:

丁酸 钠盐

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About This Item

線性公式:
CH3CH2CH2COONa
CAS號碼:
分子量::
110.09
Beilstein:
3629439
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
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品質等級

化驗

98%

形狀

powder

mp

250-253 °C (lit.)

SMILES 字串

[Na+].CCCC([O-])=O

InChI

1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1

InChI 密鑰

MFBOGIVSZKQAPD-UHFFFAOYSA-M

基因資訊

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一般說明

丁酸钠是丁酸的钠盐形式。它是一种已知抑制肿瘤细胞生长的天然化合物,并研究了其在人乳腺癌细胞系(MCF7)中的生物活性。[1]丁酸钠可能是治疗人脊髓性肌萎缩症患者的有效药物。[2]

丁酸钠是一种脂肪酸钠盐,可用作酚的酰化剂。[3]

應用

丁酸钠可作为反应剂,使用9-硼双环 [3.3.1] 壬烷(9-BBN)在 THF 中通过还原反应制备正丁醛。[4]此外,还可通过还原氧化反应转化成丁醛硼烷和氯铬酸吡啶。[5]采用基于离子液的氯亚胺试剂,丁酸钠通过光延反应与不同的醇发生反应生成酯。[6]

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

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Questions

1–4 of 4 Questions  
  1. Can a stock solution be prepared in water or PBS, and how should it be stored?

    1 answer
    1. This material is appreciable soluble in water or aqueous buffers. Prepared solutions, when filter sterilized, are expected to be stable for up to 1 year at 2 - 8°C.

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  4. What is the expected solubility in water?

    1 answer
    1. This product is soluble in water (0.1 g/ml), DMSO (<1 mg/ml), ethanol (~5 mg/ml), and PBS pH7. 2 (~10 mg/ml).

      Helpful?

Reviews

1 of 2 reviewers received a sample product or took part in a promotion
1–2 of 2 Reviews  

Active Filters

    • Review 1
    • Votes 21
    2 out of 5 stars.

    Solubility problems with latest batch of sodium butyrate

    I had good experience with Sigma's sodium butyrate during the past few years but ran into solubility problems with the latest batch, BCCG8857. The newer batch has some sort of insoluble chemical mixed in with the sodium butyrate - possibly some caking/anti-caking regent?

    In the past, I have been able to consistently dissolve 300 mg/mL of sodium butyrate in water or PBS with outstanding results - the solution was perfectly clear and there are no signs of particles. With batch BCCG8857, there are numerous white insoluble particles even when dissolving the sodium butyrate at 60 mg /mL in water. The white insoluble particles tend to adhere near the surface after centrifugation and pellets on the side of the microcentrifuge tube rather than the bottom.

    Purchase the smaller sized bottles first to test the lot before making a bigger purchase (I was told there are no other/replacement lots until they go through most of the BCCG8857 lot).

    Helpful?

    1. Response from MilliporeSigma:

      Thank you for taking the time to leave a review! We are sorry to hear that your experience did not meet expectations. We would like to learn more about your experience to see if there is anything we can do to help troubleshoot this issue. A member from our Technical Service Team will be contacting you shortly. Thank you again for your feedback.

    • Review 1
    • Vote 1
    1 out of 5 stars.

    Not dissolving in water

    BCCG8857 batch is not dissolving in water. It has to be a batch problem because I've used this concentration (16 g/L) before without any issues.

    Helpful?

    1. Response from MilliporeSigma:

      Solubility is not part of the specification for product 303410, it is not tested during quality control. However, due to a number of similar reports an investigation of lot BCCG8857 was performed and the remainder of the lot was removed from inventory. If you have not already, please contact us for a replacement free of charge by calling 1-800-325-5832.

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