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重要文件

E1024

Sigma-Aldrich

雌二醇

meets USP testing specifications

同義詞:

β-雌二醇, 17β-雌二醇, 1,3,5-雌三烯-3,17β-二醇, 3,17β-二羟基-1,3,5(10)-雌三烯, 二氢卵泡素

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About This Item

經驗公式(希爾表示法):
C18H24O2
CAS號碼:
分子量::
272.38
Beilstein:
1914275
EC號碼:
MDL號碼:
分類程式碼代碼:
12352104
PubChem物質ID:
NACRES:
NA.21
暫時無法取得訂價和供貨情況

agency

USP/NF
meets USP testing specifications

形狀

powder

mp

176-180 °C (lit.)

應用

pharmaceutical (small molecule)

SMILES 字串

O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

InChI 密鑰

VOXZDWNPVJITMN-ZBRFXRBCSA-N

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生化/生理作用

绝经前卵巢分泌的主要雌激素。
绝经前卵巢分泌的主要雌激素。雌激素通过调节基因转录并因此调节蛋白质合成来指导胚胎发生和青春期女性表型的发展。 它还诱导促性腺激素的产生,进而诱导排卵。 暴露于雌二醇会增加乳腺癌的发生率和增殖。

象形圖

Health hazardEnvironment

訊號詞

Danger

危險分類

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges


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分析證明 (COA)

Lot/Batch Number

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Fiona C Baker et al.
Psychoneuroendocrinology, 60, 96-104 (2015-07-05)
The menopausal transition is marked by increased prevalence in disturbed sleep and insomnia, present in 40-60% of women, but evidence for a physiological basis for their sleep complaints is lacking. We aimed to quantify sleep disturbance and the underlying contribution
Martial Pré et al.
Plant physiology, 147(3), 1347-1357 (2008-05-10)
Plant defense against pathogens depends on the action of several endogenously produced hormones, including jasmonic acid (JA) and ethylene. In certain defense responses, JA and ethylene signaling pathways synergize to activate a specific set of defense genes. Here, we describe
Hirotaka Ishii et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 13(4), 323-334 (2007-07-24)
It is believed that sex hormones are synthesized in the gonads and reach the brain via the blood circulation. In contrast with this view, the authors have demonstrated that sex hormones are also synthesized locally in the hippocampus and that
Agnete Overgaard et al.
Endocrinology, 155(10), 3945-3955 (2014-07-23)
Kisspeptin, neurokinin B (NKB) and dynorphin A are coexpressed in a population of neurons in the arcuate nucleus (ARC), termed KNDy neurons, which were recently recognized as important elements for the generation of GnRH pulses. However, the topographic distribution of
Yasushi Totoki et al.
Nature genetics, 46(12), 1267-1273 (2014-11-05)
Diverse epidemiological factors are associated with hepatocellular carcinoma (HCC) prevalence in different populations. However, the global landscape of the genetic changes in HCC genomes underpinning different epidemiological and ancestral backgrounds still remains uncharted. Here a collection of data from 503

Questions

1–7 of 7 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. Is product E1024 soluble in DMSO? If so, what is the recommended initial stock concentration to make?

    1 answer
    1. This product has not been tested for solubility in DMSO, however various sources report that it is soluble at 20 mg/mL.

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  4. What is the working range of Product E1024, Estradiol?

    1 answer
    1. For cell culture applications, the working range of this compound is 0.2 - 10 ng/mL.  For cell culture tested beta-estradiol, please refer to Sigma-Aldrich Prod. Nos. E2758 and E2257.

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  5. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  6. What is the solution stability of Product E1024, Estradiol?

    1 answer
    1. Since this material is air sensitive, it is best to prepare solutions fresh.

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  7. What is Product E1024, Estradiol, soluble in?

    1 answer
    1. It is soluble in ethanol, acetone, dioxane, and sparingly in vegetable oils.

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