Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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推薦產品
產品名稱
醛固酮, ≥95% (HPLC)
生物源
synthetic (organic)
品質等級
無菌
non-sterile
化驗
≥95% (HPLC)
形狀
powder
技術
cell culture | mammalian: suitable
溶解度
chloroform: 20 mg/mL, clear to slightly hazy, colorless to light yellow
運輸包裝
ambient
儲存溫度
room temp
SMILES 字串
C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@]4(C[C@H](O)[C@H]23)C=O
InChI
1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1
InChI 密鑰
PQSUYGKTWSAVDQ-ZVIOFETBSA-N
基因資訊
human ... SERPINA6(866)
rat ... Ar(24208) , Nr3c2(25672)
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一般說明
Aldosterone plays a significant role in the multi-factorial regulation of salt, potassium, blood pressure, and acid-base balance. It is also involved in maternal volume expansion during fetal development to support fetal perfusion and may contribute to the increased expression of placental growth factors. While its primary activity is associated with the kidney, aldosterone can also interact with mineralocorticoid receptors in other tissues such as the gastrointestinal tract, respiratory epithelium, myocardium, and vascular smooth muscle.[1] Aldosterone antagonists or mineralocorticoid receptor antagonists (MRAs) can be beneficial for patients with various clinical conditions, including primary aldosteronism (PA), primary and resistant hypertension, heart failure (HF), and chronic kidney disease (CKD).[2]
應用
醛固酮已被用于：
醛固酮的D-异构体被认为是具有生物活性的异构体。
生化／生理作用
其他說明
以醛和半缩醛的平衡混合物形式存在。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone-and salt-induced renal injury
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Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology
Cannavo A, et al.
Oxidative Medicine and Cellular Longevity, 2018 (2018)
Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration
Luo X, et al.
Redox Biology, 13(5), 508-521 (2017)
Aldosterone and renin measurements
Cartledge S and Lawson N
Annals of Clinical Biochemistry, 37(3), 262-278 (2000)
Seong-Mi Park et al.
Journal of clinical medicine, 8(7) (2019-07-20)
Although aldosterone has been demonstrated to induce left ventricular (LV) hypertrophy not only in primary aldosteronism but also in primary hypertension (HT), it can be affected by multiple factors, including age, and the effect of aldosterone on LV function is
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What is the Department of Transportation shipping information for this product?
1 answer-
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Is Product A9477, Aldosterone, the d- or l- isomer?
1 answer-
The A9477 is the d-Aldosterone (per our supplier), which is considered to be the biologically active isomer.
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Is Product A9477, Aldosterone, tested for solubility?
1 answer-
Yes, A9477 is tested for solubility using 20mg/ml in chloroform. For biological applications, you can solubilize aldosterone in ethanol to at least 1 mg/mL. Please refer to literature references for further solubility information.
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What is the difference between Aldosterone Products A9477 and 05521?
1 answer-
The main differences between A9477 and 05521 are the assays performed on the products. The assay results are lot specific and can be viewed on the Certificate of Analysis.
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How do I make a stock solution of Product A9477, Aldosterone?
1 answer-
To prepare a 100 μg/ml stock solution, add 5 ml of absolute ethanol to 5 mg, gently swirl to dissolve, then add 45 ml sterile medium. Freeze the stock in working aliquots, but avoid repeated freeze/thaw cycles.
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