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86500

Sigma-Aldrich

睾酮

purum, ≥99.0% (HPLC)

同義詞:

17β-羟基-3-氧代-4-雄甾烯, 17β-羟基-4-雄甾烯-3-酮, 4-雄甾烯β-17-醇-3-酮, 反式睾酮

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About This Item

經驗公式(希爾表示法):
C19H28O2
CAS號碼:
分子量::
288.42
Beilstein:
1915399
EC號碼:
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77
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等級

purum

品質等級

化驗

≥99.0% (HPLC)

形狀

powder

光學活性

[α]20/D +110±2°, c = 1% in ethanol

藥物控制

USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

mp

152-156 °C

SMILES 字串

C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O

InChI

1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1

InChI 密鑰

MUMGGOZAMZWBJJ-DYKIIFRCSA-N

基因資訊

human ... AR(367)

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生化/生理作用

睾丸分泌的睾酮在目标组织中转变为双氢睾酮,介导睾酮的多种生物作用。雄激素诱导胚胎发生和青春期的男性表型发育。

免責聲明

Sales restrictions may apply.

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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分析證明 (COA)

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Frances S Chen et al.
Social cognitive and affective neuroscience, 10(6), 797-800 (2014-09-07)
Physical size and strength are associated with dominance and threat. The current study tested (i) whether men's evaluations of male strangers would be negatively influenced by cues indicating physical formidability, and (ii) whether these evaluations would be influenced by oxytocin
David J Handelsman
The Journal of clinical endocrinology and metabolism, 91(5), 1646-1653 (2006-02-16)
The objective of the study was to review the rationale underlying the banning of human chorionic gonadotropin (hCG) and estrogen blockers (antiestrogens, specific estrogen receptor modulators, aromatase inhibitors) in sports for male and female athletes in the light of gender
Y Zimmerman et al.
Human reproduction update, 20(1), 76-105 (2013-10-02)
BACKGROUND; Combined oral contraceptives (COCs) reduce levels of androgen, especially testosterone (T), by inhibiting ovarian and adrenal androgen synthesis and by increasing levels of sex hormone-binding globulin (SHBG). Although this suppressive effect has been investigated by numerous studies over many
James R Bell et al.
American journal of physiology. Heart and circulatory physiology, 306(9), H1265-H1274 (2014-03-13)
Estrogen in females is conventionally considered a cardioprotective influence, but a role for estrogen in male cardioprotection has yet to be defined. Estrogen biosynthesis from testosterone is regulated by aromatase. Aromatase has recently been shown to be expressed in the
Andrea C Lo et al.
International journal of radiation oncology, biology, physics, 88(1), 87-93 (2013-12-18)
To determine (1) the prognostic utility of prostate-specific antigen (PSA) concentration at 45 to 60 months (48mPSA) after low-dose-rate prostate brachytherapy (LDR-PB); (2) the predictors of 48mPSA; and (3) the prognostic utility of directional trends between PSA levels at 24

Questions

1–3 of 3 Questions  
  1. How should I dissolve product #86500 Testosteron in 100% ethanol? Is it soluble? Should I store it in ethanol or dilute it in medium? Please provide more information.

    1 answer
    1. This product is soluble in chloroform at 100 mg/mL, in methanol and absolute ethanol at 0.5 mg/mL, and in a 45%(w/v) aqueous 2-hydroxypropyl-b-cyclodextrin solution at 18.2 mg/mL. This material is also soluble in vegetable oils and dioxane and slightly soluble in methyl oleate. The stock solution may be diluted with aqueous buffer or medium to the required working concentration. The stability of working solutions of this material has not been determined.

      Helpful?

  2. What is the recommended reconstitution of this product?

    1 answer
    1. This product is soluble in chloroform at 100 mg/mL, in methanol and absolute ethanol at 0.5 mg/mL, and in a 45%(w/v) aqueous 2-hydroxypropyl-b-cyclodextrin solution at 18.2 mg/mL. This material is also soluble in vegetable oils and dioxane and slightly soluble in methyl oleate.

      Helpful?

  3. Muy buenos días, a qué temperatura debe mantenerse este producto (testosterone 86500) para su almacenamiento a medio y largo plazo?

    1 answer
    1. This product may be stored at room temperature in powder form. Solutions are stable and refrigerated for up to 30 days. For long-term solution storage, aliquot and store at -20°C. This product is not assigned an expiration date or recommended retest date. Customers should routinely inspect products with no expiration date or recommended retest date to ensure they perform as expected. These products are also subject to a one-year warranty from the date of shipment. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.

      Please see the link below to review the product datasheet for the Sigma-Aldrich brand Testosterone, T1500:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/332/257/t1500dat.pdf

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