跳轉至內容
Merck
全部照片(2)

重要文件

C2505

Sigma-Aldrich

肾上腺酮

≥92% (HPLC), powder, corticosteroid hormone

同義詞:

11β,21-二羟丙酮-4-孕烯-3,20-二酮, 11β,21-二羟基黄体酮, 4-孕烯-11β,21-二醇-3,20-二酮, Kendall化合物B, Reichstein物质H

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C21H30O4
CAS號碼:
分子量::
346.46
Beilstein:
2339601
EC號碼:
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

產品名稱

肾上腺酮, ≥92%

生物源

synthetic (organic)

化驗

≥92%

形狀

powder

mp

179-183 °C (lit.)

溶解度

chloroform: 50 mg/mL, clear, colorless to faintly yellow

運輸包裝

ambient

儲存溫度

room temp

SMILES 字串

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI 密鑰

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

基因資訊

尋找類似的產品? 前往 產品比較指南

應用

皮质酮已用于:
  • 慢性治疗,研究对小鼠生长激素抑制素(SST)神经元的影响[1]
  • 作为孕鼠应激诱导激素[2]
  • 测试对小鼠抑郁相关行为的影响[3]

生化/生理作用

皮质酮是肾上腺皮质分泌的一种糖皮质激素,可同时激活盐皮质激素和糖皮质激素受体。
皮质酮通过11β-羟化酶(主要存在于肾上腺中)反应合成,[4]但也可在非肾上腺组织中合成,包括睾丸间质细胞[4]和小鼠胸腺。[5]皮质酮在下丘脑-垂体-肾上腺(HPA)轴激活后释放。它对调节新陈代谢、免疫功能和应激反应很关键。[6]皮质酮由髓系细胞应激时的HPA激活产生。[7]在亨廷顿病中可观察到皮质酮水平升高。[8]

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

未看到正確版本?

如果您需要一個特定的版本,您可以透過批號來尋找特定憑證。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Glucocorticoid production in the chicken bursa and thymus
Lechner O, et al.
International Immunology, 13(6), 769-776 (2001)
Amy E M Newman et al.
The Journal of comparative neurology, 518(18), 3662-3678 (2010-07-24)
Chronic elevations in glucocorticoids can decrease the production and survival of new cells in the adult brain. In rat hippocampus, supraphysiological doses of dehydroepiandrosterone (DHEA; a sex steroid precursor synthesized in the gonads, adrenals, and brain) have antiglucocorticoid properties. With
Corticosterone dysregulation exacerbates disease progression in the R6/2 transgenic mouse model of Huntington's disease
Dufour BD and McBride JL
Experimental neurology, 283(9), 308-317 (2016)
Chronic stress alters concentrations of corticosterone receptors in a tissue-specific manner in wild house sparrows (Passer domesticus)
Lattin CR and Romero LM
The Journal of Experimental Biology, 217(14), 2601-2608 (2014)
Somatostatin, neuronal vulnerability and behavioral emotionality
Lin LC and Sibille E
Molecular Psychiatry, 20(3), 377-377 (2015)

Questions

  1. Which reagents should be used to dissolve product C2505, and what are the recommended storage conditions after it has been dissolved?

    1 answer
    1. C2505 is soluble in Chloroform at 50 mg/mL, and should be colorless to faintly yellow in appearance.

      Although we cannot provide any verified recommendations for temperature storage of solution, other literature sources suggest that the solution can remain at room temperature if the solution stays clear for 3 days. These sources suggest that it is soluble in ethanol at 50 mg/ml, and that following reconstitution, aliquot and freeze (-20°C), for stock solutions to be stable for up to 3 months (at -20°C). There are additional sources that recommend dissolving in acetone, methanol, ethanol (10 mM), chloroform, and DMSO (100 mM). It is insoluble in water.

      Helpful?

Reviews

No rating value

Active Filters

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務