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重要文件

A6671

Sigma-Aldrich

放线酰胺素

≥98% (TLC), powder, leucine aminopeptidase inhibitor

同義詞:

3-[[1-[(2-(羟甲基)-1-吡咯烷基)羰基]-2-甲基苯基]氨基甲酰基]辛异羟肟酸

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About This Item

經驗公式(希爾表示法):
C19H35N3O5
CAS號碼:
分子量::
385.50
Beilstein:
1555250
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

產品名稱

放线酰胺素,

生物源

synthetic (organic)

品質等級

化驗

≥98% (TLC)

形狀

powder

溶解度

ethanol: 50 mg/mL, clear, colorless

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

enzyme | inhibits

儲存溫度

−20°C

SMILES 字串

CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO

InChI

1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)

InChI 密鑰

XJLATMLVMSFZBN-UHFFFAOYSA-N

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一般說明

化学结构:肽

應用

放线酰胺素已被用作抑制C57BL/6小鼠中meprinβ活性的对照。[1]它还已用于通过15N NMR波谱和等温滴定研究EcPDF与放线酰胺素的高亲和力交互效应。[2]

生化/生理作用

放线酰胺素对肽脱甲酰基酶(PDF)具有抑制作用。对革兰氏阳性和苛养型革兰氏阴性微生物有效。[3]
放线酰胺素是亮氨酸氨基肽酶的抑制剂。 放线酰胺素还被用于改善抗菌活性和抗肥胖疗法。

特點和優勢

该化合物是受体分类及信号转导手册上神经肽酶页面上的特色化合物。想要浏览手册的其他页面, 请单击此处

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor
Chen DZ, et al.
Biochemistry, 39(6), 1256-1262 (2000)
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Vaginal delivery with obstetrical trauma is a risk factor for pelvic organ prolapse later in life. Loss of fibulin-5 (FBLN5), an elastogenesis-promoting cellular matrix protein, results in prolapse in mice. Here, we evaluated effects of pregnancy, parturition, and obstetrical injury
Ligand-induced changes in the structure and dynamics of Escherichia coli peptide deformylase
Amero CD, et al.
Biochemistry, 48(32), 7595-7607 (2009)
Sonia Fieulaine et al.
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For several decades, molecular recognition has been considered one of the most fundamental processes in biochemistry. For enzymes, substrate binding is often coupled to conformational changes that alter the local environment of the active site to align the reactive groups
Diana Mader et al.
Microbes and infection, 12(5), 415-419 (2010-02-17)
The biosynthesis of proteins with N-terminal formylated methionine residues and subsequent protein deformylation are unique and invariant bacterial processes. They are exploited by the capacity of the human innate immune system to sense formylated peptides (FPs) and targeted by the

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