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Merck
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文件

A5843

Sigma-Aldrich

白蛋白 来源于人类血清

lyophilized powder, low endotoxin

同義詞:

HSA

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About This Item

CAS號碼:
EC號碼:
MDL號碼:
分類程式碼代碼:
12352202
eCl@ss:
42010201
NACRES:
NA.25

生物源

human

化驗

≥96% (agarose gel electrophoresis)

形狀

lyophilized powder

分子量

monomer calculated mol wt 66478 Da

雜質

HIV I and HIVII, HCV and HBsAg, tested negative
≤1.0 EU/mg endotoxin

溶解度

H2O: soluble 50 mg/mL

UniProt登錄號

儲存溫度

2-8°C

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

InChI 密鑰

QYSGYZVSCZSLHT-UHFFFAOYSA-N

基因資訊

human ... ALB(213)

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一般說明

白蛋白是血浆中最丰富的蛋白质。肝脏产生人白蛋白。

應用

白蛋白用于测试其对头孢托仑对耐青霉素的肺炎链球菌体外杀菌活性的影响。它已在临床上用于严重和经常危及生命的情况,例如由于外伤、烧伤和手术引起的休克和失血。
白蛋白用于研究白蛋白诱导的近端小管细胞凋亡。它还用于细胞粘连分子和表面治疗研究。

生化/生理作用

血清白蛋白可作为类固醇、脂肪酸和甲状腺激素的载体蛋白,对调节血液的胶体渗透压至关重要。研究还发现白蛋白可结合外源物质,特别是药物(例如布洛芬、华法林),并强烈影响其药代动力学。导致白蛋白氧化还原状态变化的氧化应激对其生理功能具有广泛的影响。

其他說明

更多信息参见人血清白蛋白

免責聲明

仅供研究使用。在法国,在用于科研目的时(包括进口和出口活动(《公共健康法》第L 1211-1条,第2节))该产品为管制品。购买者(即最终用户)需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves


分析證明 (COA)

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Miranda J Ridder et al.
Infection and immunity, 88(8) (2020-06-10)
Staphylococcus aureus fatty acid kinase FakA is necessary for the incorporation of exogenous fatty acids into the lipid membrane. We previously demonstrated that the inactivation of fakA leads to decreased α-hemolysin (Hla) production but increased expression of the proteases SspAB
Edina Korça et al.
Scientific reports, 10(1), 17105-17105 (2020-10-15)
Advanced glycation endproducts (AGEs) are formed in a series of non-enzymatic reactions between reducing sugars and the amino groups of proteins and accumulate during aging, diabetes mellitus, chronic kidney disease and other chronic diseases. Accumulation of AGE-modifications alters protein structure
Qiong Wen et al.
Nephrology (Carlton, Vic.), 15(1), 63-74 (2010-04-10)
SUMMARY AT A GLANCE Patients with MCD and FSGS had significant changes in the expression of several EMT-related urinary proteins through activation ERK1/2 and p38 signaling pathways. Further studies to explore the molecular mechanisms behind the distinct clinical features of
Pasquale Cervero et al.
Methods in molecular biology (Clifton, N.J.), 1046, 97-121 (2013-07-23)
Podosomes are multifunctional organelles of invasive cells that combine several key abilities including cell-matrix adhesion, extracellular matrix degradation, and mechanosensing. In combination with their high turnover rates that allow quick adaptation to the pericellular environment, podosomes are likely to play
M van de Vyver et al.
Scandinavian journal of medicine & science in sports, 26(6), 638-647 (2015-06-11)
High-intensity exercise results in immune activation. This study determined whether (a) there is concordance between serum MPO and neutrophil and/or monocyte intracellular MPO content; (b) peripheral blood mononuclear cells respond to inflammatory interleukins (ILs) by increasing intracellular signaling. Healthy male

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