暫時無法取得訂價和供貨情況
推薦產品
生物源
Nigrospora sphaerica
品質等級
蒸汽壓力
0.55 hPa ( 20 °C)
形狀
liquid
顏色
clear colorless
溶解度
H2O: miscible (completely)
抗生素活性譜
neoplastics
viruses
作用方式
DNA synthesis | interferes
enzyme | inhibits
儲存溫度
−20°C
SMILES 字串
O[C@]1([C@H]2C[C@@]3([C@@]4([C@H]([C@@]([C@@H](CC4)O)(CO)C)CC[C@H]3C2)C)CC1)CO
InChI
1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
InChI 密鑰
NOFOAYPPHIUXJR-APNQCZIXSA-N
一般說明
阿非迪霉素(Aphidicolin)是一种四环二萜抗生素，具有抗病毒和抗有丝分裂作用，可用于各种细胞系的细胞周期同步。[1]
應用
阿非迪霉素,来自球黑孢(Nigrospora sphaerica)，可用于烟草BY-2细胞的细胞周期同步。可阻滞细胞进入S期。[2]
生化／生理作用
阿非迪霉素特异性抑制负责DNA复制的DNA聚合酶α。还可抑制植物和酵母的α样DNA聚合酶，但不抑制RNA和蛋白质的合成。阿非迪霉素特异性竞争DNA聚合酶α的dCTP特异性结合位点。阿非迪霉素具有抗病毒和抗有丝分裂作用。可将细胞周期阻滞在S期。已证明其可诱导HeLa细胞凋亡。[3]
包裝
1 ml
外觀
阿非迪霉素即用型溶液，以1 mg/ml DMSO溶液的形式提供。
其他說明
保存于密闭容器内，置于干燥通风处。储存类别（TRGS 510）：可燃液体
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
188.6 °F - closed cup
閃點（°C）
87 °C - closed cup
從最近期的版本中選擇一個：
分析證明 (COA)
Lot/Batch Number
客戶也查看了
M Oguro et al.
European journal of biochemistry, 97(2), 603-607 (1979-07-01)
The mode of action by aphidicolin on DNA polymerase alpha from the nuclear fraction of sea-urchin blastulae was studied. The inhibition of DNA polymerase alpha by aphidicolin was uncompetive with activated DNA and competitive with the four deoxynucleoside triphosphates using
Anne-Hélène Quélo et al.
Journal of experimental botany, 53(369), 669-675 (2002-03-12)
Endoreduplication is a common process in plants that allows cells to increase their DNA content. In the tobacco cell cultures studied in this work it can be induced by simple hormone deprivation. Mesophyll protoplast-derived cells cultured in the presence of
New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha.
J A Huberman
Cell, 23(3), 647-648 (1981-03-01)
Varinderpal S Dhillon et al.
Teratogenesis, carcinogenesis, and mutagenesis, Suppl 1, 35-45 (2003-03-05)
Fragile sites are nonrandomly located gaps and/or breaks and their expres-sion can be induced by specific culture conditions. There are many reports in the literature that indicate that these sites can act as factors that predispose to specific chromosome aberrations
K Marheineke et al.
The Journal of biological chemistry, 276(20), 17092-17100 (2001-03-30)
DNA replication origins are located at random with respect to DNA sequence in Xenopus early embryos and on DNA replicated in Xenopus egg extracts. We have recently shown that origins fire throughout the S phase in Xenopus egg extracts. To
Active Filters
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務
