217721
RO-3306
≥95% (HPLC), liquid, Cdk1 inhibitor, Calbiochem®
同義詞:
InSolution Cdk1 Inhibitor IV, RO-3306, 5-(6-Quinolinylmethylene)-2-((2-thienylmethyl)amino)-4(5H)-thiazolone, 5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one, 5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one, 5-(6-Quinolinylmethylene)-2-((2-thienylmethyl)amino)-4(5H)-thiazolone
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About This Item
推薦產品
product name
Cdk1 Inhibitor IV, RO-3306, InSolution, ≥95%
品質等級
化驗
≥95% (HPLC)
形狀
liquid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
運輸包裝
dry ice
儲存溫度
−70°C
一般說明
A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki =2 M). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. The solid form of this compound (Cat. No. 217699) is also available.
生化／生理作用
Cell permeable: yes
Primary Target
Cdk1/B1 and Cdk1/A
Cdk1/B1 and Cdk1/A
Reversible: yes
Secondary Target
Cdk2/E, PKCδ, and SGK
Cdk2/E, PKCδ, and SGK
Target Ki: 35 nM and 110 nM for Cdk1/B1 and Cdk1/A,
包裝
Packaged under inert gas
警告
Toxicity: Irritant (B)
外觀
A 10 mM (2 mg/569 L) solution of Cdk1 Inhibitor IV, RO-3306 (Cat. No. 217699) in DMSO.
重構
Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
其他說明
Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA103, 10660.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
188.6 °F - closed cup - (refers to pure substance)
閃點（°C）
87 °C - closed cup - (refers to pure substance)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Jonathan Stahl-Meyer et al.
Cells, 11(5) (2022-03-11)
The recent discovery demonstrating that the leakage of cathepsin B from mitotic lysosomes assists mitotic chromosome segregation indicates that lysosomal membrane integrity can be spatiotemporally regulated. Unlike many other organelles, structural and functional alterations of lysosomes during mitosis remain, however
Shoumin Zhu et al.
Cell reports, 42(1), 112005-112005 (2023-01-23)
Infection with Helicobacter pylori (H. pylori) is the main risk factor for gastric cancer, a leading cause of cancer-related death worldwide. The oncogenic functions of cyclin-dependent kinase 1 (CDK1) are not fully understood in gastric tumorigenesis. Using public datasets, quantitative real-time
Scott G Wilcockson et al.
Developmental cell, 58(23), 2802-2818 (2023-09-16)
Extracellular signal-regulated kinase (Erk) signaling dynamics elicit distinct cellular responses in a variety of contexts. The early zebrafish embryo is an ideal model to explore the role of Erk signaling dynamics in vivo, as a gradient of activated diphosphorylated Erk (P-Erk)
Marina Capece et al.
Cell death and differentiation, 30(9), 2078-2091 (2023-08-04)
The discrimination of protein biological functions in different phases of the cell cycle is limited by the lack of experimental approaches that do not require pre-treatment with compounds affecting the cell cycle progression. Therefore, potential cycle-specific biological functions of a
Xiaofang Tang et al.
iScience, 26(1), 105667-105667 (2023-01-11)
Eukaryotic cells transit through the cell cycle to produce two daughter cells. Dysregulation of the cell cycle leads to cell death or tumorigenesis. Herein, we found a subunit of the ER membrane complex, EMC3, as a key regulator of cell
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