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重要文件

A0606

Sigma-Aldrich

金硫代葡萄糖 水合物

≥96% (titration)

同義詞:

Solganal, Solganol, 金硫代葡萄糖

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About This Item

經驗公式(希爾表示法):
C6H11AuO5S · xH2O
CAS號碼:
分子量::
392.18 (anhydrous basis)
EC號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

化驗

≥96% (titration)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

H2O: 5 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1

InChI 密鑰

SGVIEHTYEMEDRR-PKXGBZFFSA-M

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應用

硫代葡萄糖水合物已用于人细胞系中的氧化还原应激存活测定[1],并用于诱导小鼠肥胖表型。[2]

生化/生理作用

强效PKCι-Par6交互效应抑制剂
最近发现,临床上用于治疗类风湿关节炎的金化合物金硫代葡萄糖是一种有效的PKCiota-Par6交互效应抑制剂,IC50约为1 μM。破坏该交互效应会破坏rac1信号通路,这是非小细胞肺癌转化生长所必需的。

特點和優勢

该化合物是受体分类及信号转导手册上PKC页面上的特色化合物。想要浏览手册的其他页面, 请单击此处

象形圖

Health hazard

訊號詞

Danger

危險聲明

危險分類

Resp. Sens. 1 - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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文章

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

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