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Merck
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重要文件

901415

Sigma-Aldrich

N-(tert-Butyl)-N-((ethoxycarbonothioyl)thio)-3,5-bis(trifluoromethyl)benzamide

同義詞:

Alexanian xanthylation reagent

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About This Item

經驗公式(希爾表示法):
C16H17F6NO2S2
CAS號碼:
分子量::
433.43
MDL號碼:
分類程式碼代碼:
12352111
NACRES:
NA.22
暫時無法取得訂價和供貨情況

形狀

solid

品質等級

mp

40-46 °C

官能基

amine
fluoro

儲存溫度

−20°C

SMILES 字串

FC(F)(F)c1cc(cc(c1)C(=O)N(SC(=S)OCC)C(C)(C)C)C(F)(F)F

InChI 密鑰

QDCXZVWZLHPTDJ-UHFFFAOYSA-N

應用

As reported by the Alexanian. laboratory, this reagent is used for site-selective, intermolecular C-H xanthylation of alkanes, leading to the rapid diversification of otherwise inert C-H bonds. Once installed, the xanthate group provides direct access to diverse product analogues via several aliphatic C-H transformations, including halogenation, deuteration, vinylation, and hydroxylation. Product is best stored in foil-wrapped vials in the freezer when not in use; however, it can be weighed out on the bench without risk of decomposition. This product is offered collaboratively with UNC-Chapel Hill and Erik Alexanian.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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William L Czaplyski et al.
Journal of the American Chemical Society (2016-10-16)
Intermolecular functionalizations of aliphatic C-H bonds offer unique strategies for the synthesis and late-stage derivatization of complex molecules, but the chemical space accessible remains limited. Herein, we report a transformation significantly expanding the chemotypes accessible via C-H functionalization. The C-H

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