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Merck
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55865

Sigma-Aldrich

地高辛NHS酯

≥80% (HPLC)

同義詞:

ε-（地高辛-3-0-乙酰氨基）己酸N-羟基琥珀酰亚胺酯, 地高辛NHS

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About This Item

經驗公式（希爾表示法）:
C35H50N2O10
CAS號碼:
129273-26-3
分子量：:
658.78
MDL號碼:
MFCD02093394
分類程式碼代碼:
12352108
PubChem物質ID:
57651557
NACRES:
NA.25

化驗

≥80% (HPLC)

形狀

solid

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

[H][C@]12CC[C@]3([H])[C@]([H])(C[C@@H](O)[C@]4(C)[C@H](CC[C@]34O)C5=CC(=O)OC5)[C@@]1(C)CC[C@@H](C2)OCC(=O)NCCCCCC(=O)ON6C(=O)CCC6=O

InChI

1S/C35H50N2O10/c1-33-13-11-23(45-20-28(39)36-15-5-3-4-6-31(42)47-37-29(40)9-10-30(37)41)17-22(33)7-8-25-26(33)18-27(38)34(2)24(12-14-35(25,34)44)21-16-32(43)46-19-21/h16,22-27,38,44H,3-15,17-20H2,1-2H3,(H,36,39)/t22-,23+,24-,25-,26+,27-,33+,34+,35+/m1/s1

InChI 密鑰

KHNDABJZSPPYLE-FUGFVFQCSA-N

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應用

地高辛配基NHS酯可用于制备链霉亲和素-地高辛配基偶联物和地高辛重组Ara h1（花生成分）偶联物，用于酶联免疫吸附试验(ELISA)。

生化／生理作用

地高辛配基(Digoxigenin)是一种糖苷配基，是具有药理活性的植物毒素。效力低于地高辛。低剂量可治疗心脏疾病。地高辛配基常与另一种载荷偶联，使其活性降低或更不易进入组织。由于地高辛配基永久性连接载荷并被其完全覆盖，因而无法用作活性基团。
地高辛配基NHS酯是一种活化酯，在温和条件下与氨基反应，将地高辛配基连接蛋白质或5′-氨基取代的寡核苷酸地高辛配基标记用于免疫标记分子，以使用具有高亲和力和特异性的抗地高辛配基抗体进行检测。

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險分類

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 2

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

分析證明 (COA)

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Isotype-specific agglutination-PCR (ISAP): A sensitive and multiplex method for measuring allergen-specific IgE.
Cheng-Ting Tsai et al.
The Journal of allergy and clinical immunology, 141(5), 1901-1904 (2017-12-19)
R Antolovic et al.
European journal of biochemistry, 227(1-2), 61-67 (1995-01-15)
Na+/K(+)-ATPase from pig kidney is inactivated by protein-reactive N-hydroxysuccinimidyl derivatives of digoxigenin. Like digoxigenin, its protein-reactive derivatives N-hydroxysuccinimidyl digoxigenin-3-methylcarbonyl-epsilon-aminocaproate (HDMA), 3-amino-3-deoxydigoxigenin hemisuccinimide succinimidyl ester (ADHS), 3-iodoacetylamino-3-deoxydigoxigenin (IAD) and digoxigenin-3-O-succinyl-[2-(N-maleimido)]ethylamide (DSME) inhibited the sodium pump in the presence of Na+, Mg2+
R Antolovic et al.
The Journal of biological chemistry, 273(26), 16259-16264 (1998-06-20)
Searching for a binding protein in blood, which may be involved in the specific transport of cardiac glycosides to their receptor sites on the sodium pump, we isolated a cardiac glycoside-binding protein (CGBG) of 26 kDa from the globulin fraction
R Antolovic et al.
FEBS letters, 368(1), 169-172 (1995-07-10)
The digoxigenin derivative N-hydroxysuccinimidyl digoxigenin-3-O-methylcarbonyl-epsilon-aminocaproate (HDMA) has been shown to covalently label the ouabain binding site of the Na,K-ATPase epsilon subunit [Antolovic et al. (1995) Eur. J. Biochem. 227, 61-67]. In the present study we observed both, labeling and inactivation
Silke Metz et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(20), 8194-8199 (2011-05-04)
Bispecific antibodies that bind cell-surface targets as well as digoxigenin (Dig) were generated for targeted payload delivery. Targeting moieties are IgGs that bind the tumor antigens Her2, IGF1R, CD22, or LeY. A Dig-binding single-chain Fv was attached in disulfide-stabilized form
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