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31389

Sigma-Aldrich

葡聚糖 来源于明串珠菌 属

Mr ~40,000

同義詞:

DEXTRAN 40

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About This Item

線性公式:
(C6H10O5)n
CAS號碼:
9004-54-0
EC號碼:
232-677-5
MDL號碼:
MFCD00130935
分類程式碼代碼:
12352201
NACRES:
NA.25
暫時無法取得訂價和供貨情況

生物源

(Leuconostoc spp)

品質等級

200

形狀

powder

分子量

Mr ~40,000

技術

cryopreservation: suitable
gel permeation chromatography (GPC): suitable

損耗

≤7% loss on drying

顏色

white

mp

483  °C ((901 °F ))

溶解度

water: 1.5, clear, colorless

吸收

≤0.05 at 375 nm in H2O at 10%

適合性

suitable for additive or modifier in the separation of proteins or peptides

應用

advanced drug delivery
agriculture
sample preparation

儲存溫度

room temp

SMILES 字串

O1C(C(C(C(C1CO)O)O)O)OCC2OC(C(C(C2O)O)O)OCC(O)C(O)C(O)C(O)C=O

InChI

1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2

InChI 密鑰

FZWBNHMXJMCXLU-UHFFFAOYSA-N

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相關類別

一般說明

右旋糖酐（Dextran，又名葡聚糖）是一类主要由葡萄糖单元组成的多糖，特别是通过 α-(1-6) 键连接的 D-葡萄糖单元。其高分子量和具体结构取决于负责其生产的微生物菌株。这种均质多糖是通过细胞外右旋糖酐蔗糖酶的作用产生的，这些酶通常存在于乳酸菌属中，如明串珠菌属、乳杆菌属、链球菌属、魏斯氏菌属和片球菌属。右旋糖酐功能丰富，广泛用于生物化学、细胞生物学、药物递送研究和凝胶电泳等领域。

應用

来自明串珠菌属的葡聚糖已用于：
  • 与海水中的胚胎悬浮液混合，制备冷冻成像样品
  • 将斑马鱼幼虫的尾巴浸入水中冷冻固定
  • 在乙烯基砜修饰右旋糖酐（DX-VS）的合成中
  • 通过酯键（DX-O-MeA）合成甲基丙烯酸酯官能化葡聚糖
  • 作为 NCTC-135 组织培养基中的补充剂，以制备灌注培养基

葡聚糖是由线性α(1→6)连接的葡萄糖单元和α(1→3)连接启动的支链组成的支链葡聚糖。葡聚糖的分子量范围为10,000至150,000 Kd。 葡聚糖在多种应用中被用来作为体积扩增剂，稳定剂，基质组分，结合平台，润滑剂和物理结构组分。
Dextran 40 被用来研发移植器官改良保存溶液。葡聚糖40可以用来确定细胞紧密度和细胞层之间的通量参数。葡聚糖40可用作胶体血浆体积扩增剂。

生化／生理作用

渗透平衡：右旋糖酐通过增加溶液中的溶质浓度来帮助维持渗透平衡。这可以防止水分过多地穿过细胞膜，从而保持细胞的完整性和功能。
-冷冻保护：右旋糖酐通过在冷冻过程中在细胞和组织周围形成保护屏障来作为冷冻保护剂。这种屏障抑制冰晶的形成，冰晶会损害细胞膜和结构。
-粘度控制：右旋糖酐可以通过增加溶液的分子量来改变溶液的粘度。这种粘度变化会影响溶液的流动性，使其可用于控制各种工艺中溶液的稠度。
-药物递送：修饰右旋糖酐用作受控药物递送的载体。右旋糖酐可以包封药物并逐渐释放，提高药物的溶解度，控制释放曲线，从而改善治疗效果。
-凝胶电泳：右旋糖酐可增加凝胶电泳中样品上样溶液的密度。这种增加的密度有助于样品沉入凝胶基质中，从而在电泳过程中根据大小和电荷更精确地分离分子。
-酶稳定：右旋糖酐通过提供保护性环境来稳定酶。它在酶周围形成稳定的基质，增强酶的活性并延长其在各种生化反应中的寿命。这种保护可以防止酶变性和失活，使酶更有效地发挥作用。

特點和優勢

  • 葡聚糖平均分子量：40,000
  • 易溶于水、DMSO、甲酰胺、乙二醇和甘油
  • 用途广泛，适用于各种实验室和研究应用

其他說明

为了全面了解我们针对客户研究提供的各种葡聚糖产品，建议您访问我们的碳水化合物分类页面。
如需了解生化试剂系列的更多信息，请填写此表。

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31388

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31390

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31392

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31394

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31397

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31398

葡聚糖 来源于肠系膜明串珠菌, Mr ~200,000

31387

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09184

葡聚糖 来源于明串珠菌 属, Mr ~100,000

44886

葡聚糖 来源于明串珠菌 属, Mr ~70000

D8821

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儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

個人防護裝備

Eyeshields, Gloves, type N95 (US)

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
WXBF4050V
BCCG1297
BCCH9972
BCCJ0431
BCCG9990

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您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Peter Wick et al.
Environmental health perspectives, 118(3), 432-436 (2010-01-13)
Humans have been exposed to fine and ultrafine particles throughout their history. Since the Industrial Revolution, sources, doses, and types of nanoparticles have changed dramatically. In the last decade, the rapidly developing field of nanotechnology has led to an increase
Netta Vidavsky et al.
Journal of structural biology, 196(3), 487-495 (2016-10-04)
Many important biological questions can be addressed by studying in 3D large volumes of intact, cryo fixed hydrated tissues (⩾10,000μm3) at high resolution (5-20nm). This can be achieved using serial FIB milling and block face surface imaging under cryo conditions.
Ana Bratuša et al.
Colloids and surfaces. B, Biointerfaces, 181, 561-566 (2019-06-12)
This work describes the derivatization of dextran using N-(tert-butyloxycarbonyl)-S-(trityl)-L-cysteine in the presence of N,N'-carbonyldiimidazole (CDI) as a coupling agent. Homogeneous reactions in dimethyl sulfoxide allowed for an efficient coupling of the amino acid derivative to the polymer backbone. Derivatization was
Marie Chollat-Namy et al.
Cell death & disease, 10(10), 695-695 (2019-09-22)
Cytotoxic T lymphocytes (CTL) and natural killer cells (NK)-mediated elimination of tumor cells is mostly dependent on Granzyme B apoptotic pathway, which is regulated by the wild type (wt) p53 protein. Because TP53 inactivating mutations, frequently found in human tumors
Yang Yang et al.
Biochimica et biophysica acta, 1840(1), 288-293 (2013-10-01)
Abnormal adhesion of red blood cells (RBCs) to vascular endothelium is often associated with reduced levels of sialic acids on RBC membranes and with elevated levels of pro-adhesive plasma proteins. However, the synergistic effects of these two factors on the
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相關內容

Dextran and Polysaccharides Overview

Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, featuring a linear backbone of α-linked d-glucopyranosyl repeating units.

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    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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