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Merck
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重要文件

SMB00981

Sigma-Aldrich

2-Hydroxymelatonin

≥95% (HPLC)

同義詞:

2-OH MEL, 2-OHM, 2-OHMET, 2OHM, N-[2-(2,3-Dihydro-5-methoxy-2-oxo-1H-indol-3-yl)ethyl]acetamide, N-[2-(2-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide, AMIO

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About This Item

經驗公式(希爾表示法):
C13H16N2O3
CAS號碼:
分子量::
248.28
MDL號碼:
分類程式碼代碼:
12352205
NACRES:
NA.21
暫時無法取得訂價和供貨情況

品質等級

化驗

≥95% (HPLC)

形狀

solid

儲存溫度

2-8°C

SMILES 字串

[nH]1c2c(c(c1O)CCNC(=O)C)cc(cc2)OC

InChI 密鑰

CIEAUFSGHUWAMC-UHFFFAOYSA-N

一般說明

Melatonin (MT) is metabolized into several derivatives, including N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), N1-acetyl-5-methoxykynuramine (AMK), 6-hydroxymelatonin, 2-hydroxymelatonin, 3-hydroxymelatonin, and cyclic 3-hydroxymelatonin. MT and its metabolites are being studied for their antioxidant properties and their protective effects against oxidative stress in both mammals and in plants.

應用

Metabolomics research

其他說明

For additional information on our range of Biochemicals, please complete this form.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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Anis Ali Shah et al.
Chemosphere, 243, 125308-125308 (2019-11-14)
Cadmium level is continuously increasing in agricultural soils mainly due to anthropogenic activities. Cadmium is one of the most phytotoxic metals in the soils. The present study investigates the possible role of 2-hydroxymelatonin (2-OHMT) in assuagement of Cd-toxicity in cucumber
Sung Ho Lee et al.
Biochemical and biophysical research communications, 527(4), 941-946 (2020-05-23)
2-Hydroxymelatonin is a metabolite produced when melatonin 2-hydroxylase catalyzes melatonin. Recent studies have reported the important roles of melatonin in bone metabolism. However, the roles of 2-hydroxymelatonin in bone metabolism remains poorly understood. The purpose of this study is to
Kyoungwhan Back
The Plant journal : for cell and molecular biology, 105(2), 376-391 (2020-07-10)
Melatonin is a multifunctional biomolecule found in both animals and plants. In this review, the biosynthesis, levels, signaling, and possible roles of melatonin and its metabolites in plants is summarized. Tryptamine 5-hydroxylase (T5H), which catalyzes the conversion of tryptamine into
Ewy A Mathé et al.
Cancer research, 74(12), 3259-3270 (2014-04-17)
Lung cancer remains the most common cause of cancer deaths worldwide, yet there is currently a lack of diagnostic noninvasive biomarkers that could guide treatment decisions. Small molecules (<1,500 Da) were measured in urine collected from 469 patients with lung

Questions

  1. I want to know the solvent and solubility of 2-hydroxymelatonin (SMB00981).

    1 answer
    1. The solubility of this material has not been determined. However, other sources report that this compound is soluble in methanol and in 2 mM MES, containing 5 mM MgCl2, pH 5.6. Please see the links below to review example publications:
      https://www.sciencedirect.com/science/article/pii/S025462992300594X
      https://pmc.ncbi.nlm.nih.gov/articles/PMC8614918/
      https://pmc.ncbi.nlm.nih.gov/articles/PMC9219689/

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