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重要文件

PHR1146

Supelco

布洛芬相关化合物C(布洛芬杂质E)

Pharmaceutical Secondary Standard; Certified Reference Material

同義詞:

4′-异丁基苯乙酮, 1-乙酰基-4-异丁基苯, 1-(4-异丁基苯基)乙酮

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About This Item

經驗公式(希爾表示法):
C12H16O
CAS號碼:
分子量::
176.25
EC號碼:
分類程式碼代碼:
41116107
NACRES:
NA.24
暫時無法取得訂價和供貨情況

等級

certified reference material
pharmaceutical secondary standard

品質等級

100
300

agency

traceable to BP 557
traceable to USP 1335541

API 家族

ibuprofen

CofA

current certificate can be downloaded

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

pharmaceutical (small molecule)

形式

neat

儲存溫度

2-8°C

SMILES 字串

O=C(C)c1ccc(cc1)CC(C)C

InChI

1S/C12H16O/c1-9(2)8-11-4-6-12(7-5-11)10(3)13/h4-7,9H,8H2,1-3H3

InChI 密鑰

KEAGRYYGYWZVPC-UHFFFAOYSA-N

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一般說明

该认证标准物质(CRM)根据ISO 17034和ISO/IEC 17025生产和认证。有关使用此CRM的所有信息均可在分析证书上找到。

用于质量控制的制药二级标准品,为制药实验室和制造商提供了一种方便且经济的替代方案,可用于内部工作标准品的制备。

它是非甾体抗炎药物(NASAI)―布洛芬的杂质,并以母体药物的降解产物形式存在。它用于治疗轻度和中度疼痛,如类风湿关节炎、骨关节炎和痛经。[1]

應用

本制药二级标准品还可用于:

  • 采用反相高效液相色谱(RP-HPLC)法同时测定片剂布洛芬及其17种相关杂质的含量[1]
  • 使用薄层色谱法(TLC)和高效液相色谱法对布洛芬和法莫替丁合用片剂中的杂质进行定量分析

分析報告

这些二级标准品可追溯至USP、EP(PhEur)和BP一级标准品。

腳註

要查看该材料的分析证书示例,请在下面的栏位中输入LRAB2151。这只是一个示例证书,可能不是您收到的批次。

推薦產品

在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析(使用数字化外标)。可查看该物质的NMR谱图,只需点击几次鼠标,就能进行在线样品比对。欢迎点击了解更多,开启免费试用之旅。

相關產品

產品號碼
描述
訂價

象形圖

Exclamation markEnvironment

訊號詞

Warning

危險聲明

危險分類

Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1B

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

286.7 °F - closed cup

閃點(°C)

141.5 °C - closed cup


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

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您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Development and validation of an HPLC method for simultaneous determination of ibuprofen and 17 related compounds
Han Z, et al.
Chromatographia, 80, 1353-1360 (2017)

Questions

1–2 of 2 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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