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PHR1121

Supelco

2-苯氧基乙醇

2-Phenoxyethanol
1 of 1 reviewers received a sample product or took part in a promotion

Pharmaceutical Secondary Standard; Certified Reference Material

同義詞:

乙二醇一苯醚, 苯基乙二醇

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About This Item

線性公式:
C6H5OCH2CH2OH
CAS號碼:
122-99-6
分子量：:
138.16
Beilstein:
1364011
EC號碼:
204-589-7
MDL號碼:
MFCD00002857
分類程式碼代碼:
41116107
PubChem物質ID:
329823142
NACRES:
NA.24
暫時無法取得訂價和供貨情況

等級

certified reference material
pharmaceutical secondary standard

品質等級

300

agency

traceable to Ph. Eur. P0950000
traceable to USP 1526200

API 家族

phenoxyethanol

CofA

current certificate can be downloaded

技術

HPLC: suitable
gas chromatography (GC): suitable

bp

244-246 °C

mp

11-13 °C

密度

1.107 g/mL at 20 °C (lit.)

應用

pharmaceutical (small molecule)

形式

neat

儲存溫度

2-30°C

SMILES 字串

OCCOc1ccccc1

InChI

1S/C8H10O2/c9-6-7-10-8-4-2-1-3-5-8/h1-5,9H,6-7H2

InChI 密鑰

QCDWFXQBSFUVSP-UHFFFAOYSA-N

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相關類別

一般說明

该认证标准物质（CRM）根据ISO 17034和ISO/IEC 17025生产和认证。有关本CRM用途的所有信息参见分析证书

用于质量控制的药物二级标准品，为制药实验室和制造商制备内部工作标准提供了一种方便、高性价比的替代方案。

2-苯氧乙醇是一种常用的广谱抗菌防腐剂，在化妆品和局部用药物制剂中使用的浓度范围为0.5–1.0%。 它通过抑制线粒体中电子传递与磷酸化反应的耦合来起作用，并破坏ATP合成。 它也阻断苹果酸脱氢酶的活性，并提高细胞膜对钾离子的通透性。

應用

药物二级标准品也可用于以下应用：
  • 通过液相色谱-串联质谱（LC-MS/MS）测定大鼠血浆、尿液和7种不同组织样品中的苯氧乙醇及其主要代谢产物苯氧基乙酸
  • 开发用于定量测定市售人疫苗中2-苯氧乙醇的反相超高效液相色谱（RP-UHPLC）法
  • 通过高新液相色谱-光电二极管阵列- 电喷雾电离质谱法（HPLC-PDA-ESI/MS）筛查化妆产品（CPs）中17种应用广泛的防腐剂
  • 进行奶油样品中醋酸氢化可的松和2-苯氧乙醇的薄层色谱（TLC）-密度测定 [1]
  • 通过配备程序升温气化（PTV）进样口和火焰离子化检测器的气相色谱（GC）分析局部用制剂中的八种挥发性和半挥发性成分。

分析報告

这些二级标准提供了有效的美国药典、欧洲药典和英国药典一级标准的多重可追溯性。

腳註

想要查看本品的分析证书示例，请在下框中输入LRAC2814。这只是一个示例证书，可能与您收到的批次不符。

推薦產品

在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。

免責聲明

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

象形圖

CorrosionExclamation mark
GHS05,GHS07

訊號詞

Danger

危險聲明

H302,H318,H335

危險分類

Acute Tox. 4 Oral - Eye Dam. 1 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

258.8 °F - closed cup

閃點（°C）

126 °C - closed cup

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number

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存取文件庫

Simultaneous densitometric determination of hydrocortisone acetate and 2-phenoxyethanol in creams
Widiretani D, et al.
JPC-Journal of Planar Chromatography-Modern TLC, 26, 37-42 (2013)
Santosh K Tripathi et al.
Organic & biomolecular chemistry, 9(2), 581-587 (2010-11-05)
Syntheses of several diorganodiselenides and, in particular, a seven-membered cyclic seleninate ester derived from 2-phenoxyethanol are described. The seleninate ester was obtained from allyl (2-(2-hydroxyethoxy)phenyl) selenide through a series of oxidation and [2,3] sigmatropic rearrangement steps. The ester exhibits good
Qinghao Zhang et al.
Biochimica et biophysica acta, 1841(7), 934-943 (2014-04-01)
Biosynthesis in vertebrates of long-chain polyunsaturated fatty acids (LC-PUFA) such as arachidonic (ARA; 20:4n-6), eicosapentaenoic (EPA; 20:5n-3) and docosahexaenoic (DHA; 22:6n-3) acids requires the catalysis by fatty acyl desaturases (Fads). A vertebrate Fad with Δ4 activity catalyzing the direct conversion
J Scognamiglio et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50 Suppl 2, S244-S255 (2011-11-01)
A toxicologic and dermatologic review of 2-phenoxyethanol when used as a fragrance ingredient is presented. 2-Phenoxyethanol is a member of the fragrance structural group Aryl Alkyl Alcohols and is a primary alcohol. The AAAs are a structurally diverse class of
Tirumurugaan Krishnaswamy Gopalan et al.
PloS one, 9(6), e100018-e100018 (2014-06-24)
From an immunologist perspective, sharks are an important group of jawed cartilaginous fishes and survey of the public database revealed a great gap in availability of large-scale sequence data for the group of Chondrichthyans the elasmobranchs. In an attempt to
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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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Reviews

1 of 1 reviewers received a sample product or took part in a promotion

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  1. West Nyack, NY
    • Reviews 5
    • Vote 1
    5 out of 5 stars.

    the service was great, no issues with the order. thanks

    the service was great, no issues with the order. thanks

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